A0A0B2WQN2 · A0A0B2WQN2_METAS

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site147-152ATP (UniProtKB | ChEBI)
Binding site173a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site195-197a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site229-232a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site236a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site267ATP (UniProtKB | ChEBI)
Binding site273a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site284a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site312ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • ATP:UMP phosphotransferase
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • ORF names
      MAM_05909

Organism names

  • Taxonomic identifier
  • Strain
    • ARSEF 1941
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium

Accessions

  • Primary accession
    A0A0B2WQN2

Proteomes

Subcellular Location

Cytoplasm
Nucleus
Note: Predominantly cytoplasmic.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane64-82Helical

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region86-132Disordered
Compositional bias87-103Basic and acidic residues
Compositional bias113-132Polar residues
Region167-197NMPbind
Region266-276LID

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    36,287
  • Last updated
    2015-03-04 v1
  • Checksum
    8CB2DFB35BCB2B80
MAPRMPISCCLSSRPVAAAFRARSATPPLSCSCLLRTALGRGTRQQRLYSSEGGPTGNRDKVKFWPFIAVIAIGTAGYVGLVNRRKDMTRTGGDPKDRDQPSPHPPPHPPASSSSSSSSSSSSSSSSSAPAFSPSDVTVLFVLGGPGAGKGTQCANLVNKYGFTHLSAGDLLRAEQERPGSQFGDLIRDHIKNGLIVPMEVTVQLLENAMAEALRSNTNARKGRFLIDGFPRKLDQAHKFEESVCPARVVLFFDCPETVMEERLLERGKTSGRADDNADSIRKRFRTFVETSMPVVDYYEKQGKVIRIDATPTPDQVFARTQTRLTEEFGDEF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias87-103Basic and acidic residues
Compositional bias113-132Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZHE01000016
EMBL· GenBank· DDBJ
KHN96323.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help