A0A0B2WPM7 · A0A0B2WPM7_METAS

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9-14ITP (UniProtKB | ChEBI)
Binding site37Mg2+ (UniProtKB | ChEBI)
Binding site49ITP (UniProtKB | ChEBI)
Binding site65Mg2+ (UniProtKB | ChEBI)
Binding site65-66ITP (UniProtKB | ChEBI)
Binding site141-144ITP (UniProtKB | ChEBI)
Binding site162ITP (UniProtKB | ChEBI)
Binding site167-168ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      MAM_06709

Organism names

  • Taxonomic identifier
  • Strain
    • ARSEF 1941
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Clavicipitaceae > Metarhizium

Accessions

  • Primary accession
    A0A0B2WPM7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    185
  • Mass (Da)
    20,455
  • Last updated
    2015-03-04 v1
  • Checksum
    0052EF6A37A7A9FD
MTRCVNFVTGNPNKLREVKAMLEPGIQVRSNPIDIEEVQGSIEEVTEYKCRKAAEMVNGPVLVEDTALCFNALAGLPGPYIKWFLAGIGHEGLNNLLAAYADKSAEAVCTFGYCEGPGHKPIIFQGKCPGNIVPARGPTHFGWDPIFEHDGKTFAEMDGAGKNKISHRSRALEKLRKWFDREHQD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AZHE01000023
EMBL· GenBank· DDBJ
KHN95432.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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