A0A0B1U3S6 · A0A0B1U3S6_9BACT

  • Protein
    ATP-dependent dethiobiotin synthetase BioD
  • Gene
    bioD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-17ATP (UniProtKB | ChEBI)
Binding site16Mg2+ (UniProtKB | ChEBI)
Active site37
Binding site41substrate
Binding site48ATP (UniProtKB | ChEBI)
Binding site48Mg2+ (UniProtKB | ChEBI)
Binding site104Mg2+ (UniProtKB | ChEBI)
Binding site104-107ATP (UniProtKB | ChEBI)
Binding site164-165ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondethiobiotin synthase activity
Molecular Functionmagnesium ion binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent dethiobiotin synthetase BioD
  • EC number
  • Alternative names
    • DTB synthetase
      (DTBS
      )
    • Dethiobiotin synthase

Gene names

    • Name
      bioD
    • ORF names
      NY78_1713

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TomC
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Desulfovibrio

Accessions

  • Primary accession
    A0A0B1U3S6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,381
  • Last updated
    2015-03-04 v1
  • Checksum
    359AAB51496FF344
MTRYFITGTGTGIGKSYFSALFAQKLTAEGQTVRYIKPVATGFPEDDDAAFVAKQAGLTAADAVTLYTAAEPASPCFVFDPFPFAECVGRIEALSADRDAVLVESAGGLAVPLGQRRYNYHFALELGLEVILVVPNRLGCLSDAIVYGHFAKRHKLALSAIALNDHFAANAREADRNAAVIAEHYTSQTMYRFDAAFM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JSEH01000007
EMBL· GenBank· DDBJ
KHK02763.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp