A0A0B0NFT6 · A0A0B0NFT6_GOSAR

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site59-64ATP (UniProtKB | ChEBI)
Binding site85a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site106-108a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site133-136a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site140CMP (UniProtKB | ChEBI)
Binding site179ATP (UniProtKB | ChEBI)
Binding site183a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site194a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site222ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • ORF names
      F383_15850

Organism names

  • Taxonomic identifier
  • Strain
    • cv. AKA8401
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Malvoideae > Gossypium

Accessions

  • Primary accession
    A0A0B0NFT6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,905
  • Last updated
    2015-03-04 v1
  • Checksum
    F84B0D1042FCEB5B
MWRRVASLSSSISSSFLAQTASRLNTWESLTTGIAQQAKGVIAPKEKTPFITFVLGGPGSGKGTQCIKIVETFGFAHLSAGDLLRREIASKSADGAMILNTIKEGKIVPSQVTVQLIQKEMELSDNHKFLIDGFPRTEENRVSFERILPEWQSQIGVEPNVVLFFDCPEEEMVKRVLNRNEGRVDDNLETIKKRLTVFQALSLPVINYYSERGKLYTIKAIGTEDEIFEQVRPIFAAFENKIVLLVNFIECIITCNNGKGHPFKYPVELVHFCPGGSDRYEQTVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KN392468
EMBL· GenBank· DDBJ
KHG09861.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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