A0A0B0N4W6 · A0A0B0N4W6_GOSAR

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site85-88substrate
Binding site107substrate
Binding site108Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • ORF names
      F383_12409

Organism names

  • Taxonomic identifier
  • Strain
    • cv. AKA8401
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Malvoideae > Gossypium

Accessions

  • Primary accession
    A0A0B0N4W6

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    170
  • Mass (Da)
    18,142
  • Last updated
    2015-03-04 v1
  • Checksum
    66ECC1D1D40FBFAA
MKTYMAAFATAEACDSNTALLASGELRALEPIFKIYGQRRSFSGPIVTLKVFEDNVLVRQLLETRGEGRVLVIDGGGSKRCALVGGNLAQSAQNMGWSGIVVNGCIRDVDEINACDIGVRALGSNPLKSNKKAIGEKHAPISIAGTLIRDGEWLYADSDGILISKMELSI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRRC01483243
EMBL· GenBank· DDBJ
KHG07830.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp