A0A0B0N395 · A0A0B0N395_GOSAR

Function

function

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site109[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site114[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site120[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site140[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site144[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site147[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site356[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionlipoate synthase activity
Molecular Functionmetal ion binding
Biological Processprotein lipoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoyl synthase, mitochondrial
  • EC number
  • Alternative names
    • Lipoate synthase
      (LS
      ; Lip-syn
      )
    • Lipoic acid synthase

Gene names

    • Name
      LIP1
    • ORF names
      F383_33353

Organism names

  • Taxonomic identifier
  • Strain
    • cv. AKA8401
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Malvoideae > Gossypium

Accessions

  • Primary accession
    A0A0B0N395

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the radical SAM superfamily. Lipoyl synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    377
  • Mass (Da)
    41,438
  • Last updated
    2015-03-04 v1
  • Checksum
    27255E8F12B2A4C5
MMQSRFTSVVRAISSAAKARPFSSTIDSPTPTKPDFPPTLAGLRARLAAESPTLSDFFGLQTNNLYSVEVGTKKKPLPKPKWMRESIPGGEKYVQIKAKLRELKLHTVCEEARCPNLGECWSGGETGTATATIMILGDTCTRGCRFCNVKTSRTPPPPDPDEPRNVAEAIASWGLDYVVITSVDRDDLADQGSGHFAETVEKLKTLKPNMLIEALVPDFRADAACVEKVAKSGLDVFAHNIETVEELQRVVRDHRANFKQSLDVLMMAKEYVPAGTLTKTSIMLGCGETPDQVVKTMEKVRAAGVDVMTFGQYMRPSKRHMPVSEYITPEAFGKYRALGMEMGFRYVASGPMVRSSYKAGEFYIKSMIESDRSAAAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRRC01468049
EMBL· GenBank· DDBJ
KHG07122.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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