A0A0B0MBW3 · A0A0B0MBW3_GOSAR

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site81-84substrate
Binding site103substrate
Binding site104Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase

Gene names

    • ORF names
      F383_02814
      , F383_23714
      , F383_25833

Organism names

  • Taxonomic identifier
  • Strain
    • cv. AKA8401
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Malvales > Malvaceae > Malvoideae > Gossypium

Accessions

  • Primary accession
    A0A0B0MBW3

Proteomes

Interaction

Subunit

Homotrimer.

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    166
  • Mass (Da)
    17,776
  • Last updated
    2015-03-04 v1
  • MD5 Checksum
    914DD4AD2C12742FB5723854131CCB32
MALVTTAEVCDANPQLIVSGELRALQPIFQIYGRRPVFSGPIVTLKVFEDNVLIREFLEEKGNGRVLVVDGGGSLRCAILGGNPVVQAQNNGWAGIVVNGCVRDVDEINGCDIGVRALHSHPMKANKKGIGEKHVPITIAGTRICDGEWLYADTDGILVSKTELSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JRRC01088792
EMBL· GenBank· DDBJ
KHF99657.1
EMBL· GenBank· DDBJ
Genomic DNA
JRRC01238322
EMBL· GenBank· DDBJ
KHG02070.1
EMBL· GenBank· DDBJ
Genomic DNA
KN406830
EMBL· GenBank· DDBJ
KHG16728.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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