A0A0A7V8F8 · A0A0A7V8F8_9ARCH

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site12
Active site131

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisF
  • EC number
  • Alternative names
    • IGP synthase cyclase subunit
    • IGP synthase subunit HisF
    • ImGP synthase subunit HisF
      (IGPS subunit HisF
      )

Gene names

    • Name
      hisF
    • ORF names
      A7X95_07260
      , T478_1295

Organism names

Accessions

  • Primary accession
    A0A0A7V8F8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HisA/HisF family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    267
  • Mass (Da)
    29,260
  • Last updated
    2015-03-04 v1
  • Checksum
    7EC5BB916EFD0355
MVLTKRIIPCLDVANGRVVKGLNFESIKDAGDPVQLAEKYSNEGADELVFLDITASSEQRETIKSLVKKIAEVIDIPFTVGGGVKSLQHARDILLNGADKVAINTGAVKNPEVITELMELFGKQCVVVAIDSRRNYNLEKGKNIFSENGKQFWFEVFIYGGKKGTGLDVIDWSKKIEELGAGEILLTSIDRDGTKDGYDTLLTNEIVHAVGIPVIASGGCGKPEDMIDIFKNTEVNAALAASIFHYETHSVNRVKEMIKENGIDVRY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP007026
EMBL· GenBank· DDBJ
AJA92950.1
EMBL· GenBank· DDBJ
Genomic DNA
LXWN01000003
EMBL· GenBank· DDBJ
PTL87103.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help