A0A0A7KWA8 · A0A0A7KWA8_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2961 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus
Accessions
- Primary accessionA0A0A7KWA8
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 722-745 | Helical | ||||
Sequence: WVVLLFLLLADARVCACLWMLLLL | ||||||
Transmembrane | 757-782 | Helical | ||||
Sequence: ILHAVSAAGTNGIVCFIISFIAAWYI | ||||||
Transmembrane | 794-812 | Helical | ||||
Sequence: YLGLWSFSLLLLALPQQAY | ||||||
Transmembrane | 824-842 | Helical | ||||
Sequence: LVLLVIISVLTLTPAYKIL | ||||||
Transmembrane | 877-897 | Helical | ||||
Sequence: IIWVAAILCPGVMFDITKWLL | ||||||
Transmembrane | 1664-1692 | Helical | ||||
Sequence: WVLVGGVLAALAAYCLTTGSVVIVGRIVL | ||||||
Transmembrane | 1829-1849 | Helical | ||||
Sequence: AASAFVGAGIAGAAIGSIGLG | ||||||
Transmembrane | 1855-1874 | Helical | ||||
Sequence: ILAGYGAGVAGALVAFKVMS | ||||||
Transmembrane | 1886-1906 | Helical | ||||
Sequence: LLPAILSPGALVVGVVCAAIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-79 | Disordered | ||||
Sequence: MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKDRRSTGKSWGRP | ||||||
Compositional bias | 47-74 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKDRRSTGK | ||||||
Domain | 907-1030 | Peptidase C18 | ||||
Sequence: RSALTSTPYFVRAQALLRVCAAVRHLSGGKYVQMMLLTLGRWTGTYIYDHLTPLQDWAHAGLRDLAVAVEPVVFSNMETKIITWGAETAACGDIISGLPVSARRGREILLGPADSLEGQGWRLL | ||||||
Domain | 1031-1212 | Peptidase S29 | ||||
Sequence: APITAYSQQTRGLLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPSGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPSGHAVGIFRAAVCTRGVAKAVDFIPVESMETTMRSP | ||||||
Domain | 1221-1373 | Helicase ATP-binding | ||||
Sequence: PAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAYGVNPNIRTGVRTITTGAPITYSTYGKFLADGGCSGGAYDIIMCDECHSTDATSILGIGTVLDQAESAGVRLAVLATATPPGSVTVPHPNIEEVGLSN | ||||||
Domain | 1365-1542 | Helicase C-terminal | ||||
Sequence: NIEEVGLSNTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLSALGLNAVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTMPQDAVSRSQRRGRTGRGRTGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVR | ||||||
Region | 2186-2223 | Disordered | ||||
Sequence: TAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTQH | ||||||
Compositional bias | 2199-2223 | Polar residues | ||||
Sequence: PPSLASSSASQLSAPSLKATCTTQH | ||||||
Compositional bias | 2357-2389 | Polar residues | ||||
Sequence: GSSGSSAVDSSTATAPLNQTSDDGDTGSDVESH | ||||||
Region | 2357-2411 | Disordered | ||||
Sequence: GSSGSSAVDSSTATAPLNQTSDDGDTGSDVESHSSMPPLEGEPGDPDLSDGSWST | ||||||
Domain | 2637-2755 | RdRp catalytic | ||||
Sequence: PMGFAYDTRCFDSTVTENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKASAACRAAKLRDCTMLVCGDDLVVICESAGTQDD |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length2,961
- Mass (Da)322,073
- Last updated2015-03-04 v1
- Checksum0B7FE78E245C6E76
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 47-74 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKDRRSTGK | ||||||
Compositional bias | 2199-2223 | Polar residues | ||||
Sequence: PPSLASSSASQLSAPSLKATCTTQH | ||||||
Compositional bias | 2357-2389 | Polar residues | ||||
Sequence: GSSGSSAVDSSTATAPLNQTSDDGDTGSDVESH | ||||||
Non-terminal residue | 2961 | |||||
Sequence: P |