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A0A0A7HSX6 · A0A0A7HSX6_9FLOR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A0A7HSX6

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-37Helical
Transmembrane57-82Helical
Transmembrane94-121Helical
Transmembrane141-165Helical
Transmembrane177-201Helical
Transmembrane213-236Helical
Transmembrane248-269Helical
Transmembrane281-306Helical
Transmembrane318-341Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_500738826022-357Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-357Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    357
  • Mass (Da)
    39,394
  • Last updated
    2015-03-04 v1
  • MD5 Checksum
    BBFBB28CD033EFF442EF31117AED69DA
PDMAFPRLNNISFWLLPPSLCLLLASAIVEVGVGTGWTVYPPLSSIQSHSGGAVDLAIFSLHISGASSILGAINFISTILNMRNPGQSMYRMPLFVWSIFITAFLLLLAVPVLAGAITMLLTDRNFNTAFFDPAGGGDPVLYQHLFWFFGHPEVYILILPGFGMVSHIVATFSRKPVFGYIGMVYAMVSIGVLGFIVWAHHMYTVGLDVDTRAYFTAATMIIAVPTGIKIFSWIATMWEGSLHFKTPMLFATGFIFLFTIGGLTGIVLANSGLDISLHDTYYVVAHFHYVLSMGAVFAIFAGFYYWFGKITGVQYPELLGKIHFWSTFIGVNLTFMPMHFLGLAGMPRRIPDYPDAY

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue357

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM502162
EMBL· GenBank· DDBJ
AIZ09159.1
EMBL· GenBank· DDBJ
Genomic DNA
KP099565
EMBL· GenBank· DDBJ
AJT47813.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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