A0A0A7GGB1 · A0A0A7GGB1_GEOAI

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site97Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site98Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site136substrate
Binding site158substrate
Site168-169Cleavage; by autolysis
Active site169Nucleophile
Binding site169substrate
Binding site245substrate
Binding site370substrate
Binding site375substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      GACE_0930

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SBH6
  • Taxonomic lineage
    Archaea > Euryarchaeota > Archaeoglobi > Archaeoglobales > Archaeoglobaceae > Geoglobus

Accessions

  • Primary accession
    A0A0A7GGB1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50232549921-168Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023254991169-375Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    375
  • Mass (Da)
    41,014
  • Last updated
    2015-03-04 v1
  • Checksum
    5A550B9ABC560104
MDFKPLKCYGIKEGKYGVGVAVIDGKIHAVYTKNRIKAAPVIFNQNNLCERIRGIIVNSGNANAFTGDEGMRMAERMAAFLAEKLGCDVSEVAIASTGVIGVLPDMEKIEQLAEEVLKRLESSEAGVKAFARAIMTTDRYPKISFREVDRVRVLGIAKGAGMIAPNMATMLAFIFTNAKTSEMDAVFRKCVDETFNRITVDGDTSTNDTVFLVTTEEIEVPREKLESLMRDVMLELAEMIVMDGEGATKLFYVHVYGAKSDEDADRVARAVANSLLVKTAIYGEDPNFGRIIAAAGYSGAEVDDVITLKLRSGYGEAVIVDRGRVAEENIGQAERVMKARKLEIILDLHKGDGYGFAIGCDLTHDYVELNSAYTT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009552
EMBL· GenBank· DDBJ
AIY89977.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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