A0A0A7E6D8 · A0A0A7E6D8_HUMAN

  • Protein
    Aminopeptidase
  • Gene
    ERAP1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

1941100200300400500600700800900
Type
IDPosition(s)Description
Binding site353Zn2+ (UniProtKB | ChEBI); catalytic
Active site354Proton acceptor
Binding site357Zn2+ (UniProtKB | ChEBI); catalytic
Binding site376Zn2+ (UniProtKB | ChEBI); catalytic
Site438Transition state stabilizer

GO annotations

AspectTerm
Molecular Functionaminopeptidase activity
Molecular Functionmetallopeptidase activity
Molecular Functionzinc ion binding
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminopeptidase
  • EC number

Gene names

    • Name
      ERAP1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A0A7E6D8

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-32
ChainPRO_500203875733-941Aminopeptidase

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain60-246Aminopeptidase N-like N-terminal
Domain281-484Peptidase M1 membrane alanine aminopeptidase
Domain597-916ERAP1-like C-terminal

Sequence similarities

Belongs to the peptidase M1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    941
  • Mass (Da)
    107,085
  • Last updated
    2015-03-04 v1
  • Checksum
    6D5C5E4864AC0F80
MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIPVHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPLQVLEHPPQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITVTVAHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVSTPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQRGFPLITITVRGRNVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFSLKTKTDVLILPEEVEWIKFNVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEGSVSERMLRSQLLLLACAHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTEGWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIGRNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHVVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue941

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM357887
EMBL· GenBank· DDBJ
AIY60629.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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