A0A0A7BTJ2 · A0A0A7BTJ2_9MUSC

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Empidoidea > Dolichopodidae > Diaphorinae > Chrysotus

Accessions

  • Primary accession
    A0A0A7BTJ2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-204Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    204
  • Mass (Da)
    21,916
  • Last updated
    2015-03-04 v1
  • Checksum
    F8518151B801E75C
TLYFIFGAWAGMVGTSLSIIVRMELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWMLPPSLTLLLASSMVENGAGTGWTVYPPLSAGIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGITFDRMPLFVWSVVITAILLLLSLPVLAGAITMLLTDRNLNTSFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue204

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ087463
EMBL· GenBank· DDBJ
AHM17120.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ092735
EMBL· GenBank· DDBJ
AHM22392.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ444431
EMBL· GenBank· DDBJ
AHZ87719.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ444500
EMBL· GenBank· DDBJ
AHZ87788.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ445288
EMBL· GenBank· DDBJ
AHZ88575.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ207946
EMBL· GenBank· DDBJ
AHZ92790.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ208096
EMBL· GenBank· DDBJ
AHZ92940.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ208698
EMBL· GenBank· DDBJ
AHZ93541.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ637597
EMBL· GenBank· DDBJ
AID15728.1
EMBL· GenBank· DDBJ
Genomic DNA
KM909058
EMBL· GenBank· DDBJ
ALN06656.1
EMBL· GenBank· DDBJ
Genomic DNA
KM954998
EMBL· GenBank· DDBJ
ALR55628.1
EMBL· GenBank· DDBJ
Genomic DNA
KM956078
EMBL· GenBank· DDBJ
ALR56708.1
EMBL· GenBank· DDBJ
Genomic DNA
KM958171
EMBL· GenBank· DDBJ
ALR58798.1
EMBL· GenBank· DDBJ
Genomic DNA
KM959157
EMBL· GenBank· DDBJ
ALR59782.1
EMBL· GenBank· DDBJ
Genomic DNA
KM962191
EMBL· GenBank· DDBJ
ALR62812.1
EMBL· GenBank· DDBJ
Genomic DNA
KR387205
EMBL· GenBank· DDBJ
AMV93722.1
EMBL· GenBank· DDBJ
Genomic DNA
KR392363
EMBL· GenBank· DDBJ
AMV98880.1
EMBL· GenBank· DDBJ
Genomic DNA
KR382503
EMBL· GenBank· DDBJ
AMW68785.1
EMBL· GenBank· DDBJ
Genomic DNA
KR394382
EMBL· GenBank· DDBJ
AMW73402.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp