A0A0A7BB20 · A0A0A7BB20_9MUSC
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids210 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Empidoidea > Dolichopodidae > Diaphorinae > Chrysotus
Accessions
- Primary accessionA0A0A7BB20
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | |||
Transmembrane | 37-59 | Helical | |||
Transmembrane | 133-155 | Helical | |||
Transmembrane | 167-194 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Sequence
- Sequence statusFragment
- Length210
- Mass (Da)22,371
- Last updated2015-03-04 v1
- ChecksumB1BE30FCF1067851
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 210 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ086458 EMBL· GenBank· DDBJ | AHM16115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ087436 EMBL· GenBank· DDBJ | AHM17093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ088406 EMBL· GenBank· DDBJ | AHM18063.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ090425 EMBL· GenBank· DDBJ | AHM20082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ164543 EMBL· GenBank· DDBJ | AHN87385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ167154 EMBL· GenBank· DDBJ | AHN89996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ445610 EMBL· GenBank· DDBJ | AHZ88897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ207467 EMBL· GenBank· DDBJ | AHZ92317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ207952 EMBL· GenBank· DDBJ | AHZ92796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ208782 EMBL· GenBank· DDBJ | AHZ93625.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ208876 EMBL· GenBank· DDBJ | AHZ93718.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ209040 EMBL· GenBank· DDBJ | AHZ93882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ209206 EMBL· GenBank· DDBJ | AHZ94048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ209313 EMBL· GenBank· DDBJ | AHZ94154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ209403 EMBL· GenBank· DDBJ | AHZ94244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM897767 EMBL· GenBank· DDBJ | ALK68075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM918706 EMBL· GenBank· DDBJ | ALK77026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM919626 EMBL· GenBank· DDBJ | ALK77946.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM901692 EMBL· GenBank· DDBJ | ALM99297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM903956 EMBL· GenBank· DDBJ | ALN01562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM905319 EMBL· GenBank· DDBJ | ALN02925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM906082 EMBL· GenBank· DDBJ | ALN03685.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM907664 EMBL· GenBank· DDBJ | ALN05266.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM911431 EMBL· GenBank· DDBJ | ALN09028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM964853 EMBL· GenBank· DDBJ | ALN52711.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM959893 EMBL· GenBank· DDBJ | ALR60518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM968850 EMBL· GenBank· DDBJ | ALR64750.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM969581 EMBL· GenBank· DDBJ | ALR65481.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR393280 EMBL· GenBank· DDBJ | AMW72300.1 EMBL· GenBank· DDBJ | Genomic DNA |