A0A0A7B1N7 · A0A0A7B1N7_9DIPT

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Mansoniini > Coquillettidia

Accessions

  • Primary accession
    A0A0A7B1N7

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane93-113Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-210Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    210
  • Mass (Da)
    22,333
  • Last updated
    2015-03-04 v1
  • Checksum
    1AA2DADF861D4FA6
TLYFIFGAWSGMVGTSLSILIRAELSQPGVFIGNDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWMLPPSLTLLLSGGMVESGAGTGWTVYPPLSAGTAHAGASVDLSIFSLHLAGISSILGAVNFITTVINMRTSGITLDRLPLFVWSVVITAVLLLLSLPVLAGAITMLLTDRNLNTSFFDPTGGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue210

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ083304
EMBL· GenBank· DDBJ
AHM12961.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ083617
EMBL· GenBank· DDBJ
AHM13274.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ083940
EMBL· GenBank· DDBJ
AHM13597.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ084291
EMBL· GenBank· DDBJ
AHM13948.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ084925
EMBL· GenBank· DDBJ
AHM14582.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ085601
EMBL· GenBank· DDBJ
AHM15258.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ085719
EMBL· GenBank· DDBJ
AHM15376.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ086503
EMBL· GenBank· DDBJ
AHM16160.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ086698
EMBL· GenBank· DDBJ
AHM16355.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ087708
EMBL· GenBank· DDBJ
AHM17365.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ087801
EMBL· GenBank· DDBJ
AHM17458.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ088317
EMBL· GenBank· DDBJ
AHM17974.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ088756
EMBL· GenBank· DDBJ
AHM18413.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ089252
EMBL· GenBank· DDBJ
AHM18909.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ089306
EMBL· GenBank· DDBJ
AHM18963.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ089679
EMBL· GenBank· DDBJ
AHM19336.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ089951
EMBL· GenBank· DDBJ
AHM19608.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ090463
EMBL· GenBank· DDBJ
AHM20120.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ091380
EMBL· GenBank· DDBJ
AHM21037.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ092341
EMBL· GenBank· DDBJ
AHM21998.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ092425
EMBL· GenBank· DDBJ
AHM22082.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ092474
EMBL· GenBank· DDBJ
AHM22131.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ093163
EMBL· GenBank· DDBJ
AHM22820.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ163736
EMBL· GenBank· DDBJ
AHN86578.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ164804
EMBL· GenBank· DDBJ
AHN87646.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ165360
EMBL· GenBank· DDBJ
AHN88202.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ165771
EMBL· GenBank· DDBJ
AHN88613.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ166284
EMBL· GenBank· DDBJ
AHN89126.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ167443
EMBL· GenBank· DDBJ
AHN90285.1
EMBL· GenBank· DDBJ
Genomic DNA
KT705397
EMBL· GenBank· DDBJ
ALF96194.1
EMBL· GenBank· DDBJ
Genomic DNA
KR657334
EMBL· GenBank· DDBJ
AOD46572.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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