A0A0A7B1N7 · A0A0A7B1N7_9DIPT
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids210 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Mansoniini > Coquillettidia
Accessions
- Primary accessionA0A0A7B1N7
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: FGAWSGMVGTSLSILIRAEL | ||||||
Transmembrane | 37-59 | Helical | ||||
Sequence: IYNVIVTAHAFIMIFFMVMPIMI | ||||||
Transmembrane | 93-113 | Helical | ||||
Sequence: LTLLLSGGMVESGAGTGWTVY | ||||||
Transmembrane | 133-155 | Helical | ||||
Sequence: SLHLAGISSILGAVNFITTVINM | ||||||
Transmembrane | 167-194 | Helical | ||||
Sequence: LFVWSVVITAVLLLLSLPVLAGAITMLL |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-210 | Cytochrome oxidase subunit I profile | ||||
Sequence: TLYFIFGAWSGMVGTSLSILIRAELSQPGVFIGNDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWMLPPSLTLLLSGGMVESGAGTGWTVYPPLSAGTAHAGASVDLSIFSLHLAGISSILGAVNFITTVINMRTSGITLDRLPLFVWSVVITAVLLLLSLPVLAGAITMLLTDRNLNTSFFDPTGGG |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length210
- Mass (Da)22,333
- Last updated2015-03-04 v1
- Checksum1AA2DADF861D4FA6
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Non-terminal residue | 210 | |||||
Sequence: G |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ083304 EMBL· GenBank· DDBJ | AHM12961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ083617 EMBL· GenBank· DDBJ | AHM13274.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ083940 EMBL· GenBank· DDBJ | AHM13597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ084291 EMBL· GenBank· DDBJ | AHM13948.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ084925 EMBL· GenBank· DDBJ | AHM14582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ085601 EMBL· GenBank· DDBJ | AHM15258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ085719 EMBL· GenBank· DDBJ | AHM15376.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ086503 EMBL· GenBank· DDBJ | AHM16160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ086698 EMBL· GenBank· DDBJ | AHM16355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ087708 EMBL· GenBank· DDBJ | AHM17365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ087801 EMBL· GenBank· DDBJ | AHM17458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ088317 EMBL· GenBank· DDBJ | AHM17974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ088756 EMBL· GenBank· DDBJ | AHM18413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ089252 EMBL· GenBank· DDBJ | AHM18909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ089306 EMBL· GenBank· DDBJ | AHM18963.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ089679 EMBL· GenBank· DDBJ | AHM19336.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ089951 EMBL· GenBank· DDBJ | AHM19608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ090463 EMBL· GenBank· DDBJ | AHM20120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ091380 EMBL· GenBank· DDBJ | AHM21037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ092341 EMBL· GenBank· DDBJ | AHM21998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ092425 EMBL· GenBank· DDBJ | AHM22082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ092474 EMBL· GenBank· DDBJ | AHM22131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ093163 EMBL· GenBank· DDBJ | AHM22820.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ163736 EMBL· GenBank· DDBJ | AHN86578.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ164804 EMBL· GenBank· DDBJ | AHN87646.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ165360 EMBL· GenBank· DDBJ | AHN88202.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ165771 EMBL· GenBank· DDBJ | AHN88613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ166284 EMBL· GenBank· DDBJ | AHN89126.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ167443 EMBL· GenBank· DDBJ | AHN90285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT705397 EMBL· GenBank· DDBJ | ALF96194.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KR657334 EMBL· GenBank· DDBJ | AOD46572.1 EMBL· GenBank· DDBJ | Genomic DNA |