A0A0A7A8T3 · A0A0A7A8T3_9ODON

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COX1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Palaeoptera > Odonata > Zygoptera > Euphaeidae > Euphaea

Accessions

  • Primary accession
    A0A0A7A8T3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-42Helical
Transmembrane54-76Helical
Transmembrane110-130Helical
Transmembrane150-172Helical
Transmembrane184-211Helical
Transmembrane231-259Helical
Transmembrane271-292Helical
Transmembrane304-327Helical
Transmembrane339-360Helical
Transmembrane380-401Helical
Transmembrane413-431Helical
Transmembrane451-474Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-513Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    514
  • Mass (Da)
    56,275
  • Last updated
    2015-03-04 v1
  • Checksum
    1D60ADB47CCACFB0
MVEMQQWLFSTNHKDIGTLYLMFGAWAGMVGTALSMLIRIELGQPGSLIGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRLNNMSFWLLPPSITLLLTSSLVESGAGTGWTVYPPLAGAIAHAGGSVDLTIFSLHLAGVSSILGAINFISTTINMKAPGMKMDQMPLFVWAVVITALLLLLSLPVLAGAITMLLTDRNINTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIIAQESGKKETFGVLGMIYAMIAIGILGFVVWAHHMFTVGMDVDTRAYFTSATMVIAVPTGIKIFSWLATLHGTQLSYSPSLLWALGFVFLFTVGGLTGVVLANSSIDIAMHDTYYVVAHFHYVLSMGAVFAIMGGLIHWFPLFTGTTMDNSMLKTQFATMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTAWNIISTLGSSISMVAVVMLLFIIWEAMASQRQVLSPSALNTSIEWYQKTPPTEHSYSELPLMVK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF718295
EMBL· GenBank· DDBJ
AHC02135.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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