A0A0A7A5G9 · A0A0A7A5G9_9POXV

  • Protein
    Virion membrane protein OPG144 precursor
  • Gene
    VACV_BRZ_SERRO2_135
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Envelope protein which participates in virus morphogenesis. Needed for an early step in viral crescent membrane formation by interacting with OPG125 scaffold protein. Its interaction with OPG125 scaffold protein leads to the formation of rigid, crescent-shaped membranes that assemble around the cytoplasmic virus factory. Acts as a membrane anchor for the protein OPG154. OPG144-OPG154 virus envelope protein might be involved in fusion or attachment, and can further associate with OPG153.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentvirion membrane

Names & Taxonomy

Protein names

  • Recommended name
    Virion membrane protein OPG144 precursor

Gene names

    • Name
      VACV_BRZ_SERRO2_135
    • ORF names
      VACV_CTGV_CM01_137

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Brazil Serro 2
    • Cantagalo
  • Taxonomic lineage
    Viruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Chitovirales > Poxviridae > Chordopoxvirinae > Orthopoxvirus

Accessions

  • Primary accession
    A0A0A7A5G9

Proteomes

Subcellular Location

Virion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane58-75Helical
Transmembrane81-103Helical
Transmembrane115-133Helical
Transmembrane139-157Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. Interacts (via N-terminus) with OPG125 scaffold; this interaction helps OPG125 to associate with membranes. Interacts with OPG140. Interacts with OPG154; this interaction allows OPG154 to be anchored in the mature virion (MV) membrane. Part of a complex composed of OPG144, OPG153 and OPG154.

Family & Domains

Sequence similarities

Belongs to the orthopoxvirus OPG144 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    22,998
  • Last updated
    2015-03-04 v1
  • Checksum
    24759AF6FC1634DF
MSYLRYYNMLDDFSAGAGVLDKDLFTEEQQQSFMPKDGGMMQNDYGGMNDYLGIFKNNDVRTLLGLILFVLALYSPPLISILMIFISSFLLPLTSLVITYCLVTQMYRGGNGNTVGMSIVCIVAAVIIMAINVFTNSQIFNIISYIILFILFFAYVMNIERQDYRRSINVTIPKQYTCNKPYTAGNKVDVDIPTFNSLNTDDY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF179385
EMBL· GenBank· DDBJ
AHB35775.1
EMBL· GenBank· DDBJ
Genomic DNA
KT013210
EMBL· GenBank· DDBJ
ALF36294.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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