A0A0A7A5G9 · A0A0A7A5G9_9POXV
- ProteinVirion membrane protein OPG144 precursor
- GeneVACV_BRZ_SERRO2_135
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids203 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Envelope protein which participates in virus morphogenesis. Needed for an early step in viral crescent membrane formation by interacting with OPG125 scaffold protein. Its interaction with OPG125 scaffold protein leads to the formation of rigid, crescent-shaped membranes that assemble around the cytoplasmic virus factory. Acts as a membrane anchor for the protein OPG154. OPG144-OPG154 virus envelope protein might be involved in fusion or attachment, and can further associate with OPG153.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | virion membrane |
Names & Taxonomy
Protein names
- Recommended nameVirion membrane protein OPG144 precursor
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Chitovirales > Poxviridae > Chordopoxvirinae > Orthopoxvirus
Accessions
- Primary accessionA0A0A7A5G9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 58-75 | Helical | |||
Transmembrane | 81-103 | Helical | |||
Transmembrane | 115-133 | Helical | |||
Transmembrane | 139-157 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked. Interacts (via N-terminus) with OPG125 scaffold; this interaction helps OPG125 to associate with membranes. Interacts with OPG140. Interacts with OPG154; this interaction allows OPG154 to be anchored in the mature virion (MV) membrane. Part of a complex composed of OPG144, OPG153 and OPG154.
Structure
Family & Domains
Sequence similarities
Belongs to the orthopoxvirus OPG144 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length203
- Mass (Da)22,998
- Last updated2015-03-04 v1
- Checksum24759AF6FC1634DF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF179385 EMBL· GenBank· DDBJ | AHB35775.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT013210 EMBL· GenBank· DDBJ | ALF36294.1 EMBL· GenBank· DDBJ | Genomic DNA |