A0A0A6YXY1 · A0A0A6YXY1_MOUSE

  • Protein
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • Gene
    Ntmt1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Catalytic activity

GO annotations

AspectTerm
Molecular Functionmethyltransferase activity
Biological ProcessN-terminal protein amino acid methylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
  • EC number
  • Alternative names
    • Alpha N-terminal protein methyltransferase 1A
    • Methyltransferase-like protein 11A
    • X-Pro-Lys N-terminal protein methyltransferase 1A

Gene names

    • Name
      Ntmt1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A0A6YXY1

Proteomes

Organism-specific databases

Subcellular Location

Nucleus

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the methyltransferase superfamily. NTM1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    118
  • Mass (Da)
    13,305
  • Last updated
    2015-02-04 v1
  • Checksum
    268A9FFD1068E72D
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKTYLGEEGKRVRNYFCCG

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8R2U4NTM1A_MOUSENtmt1223
A2APZ2A2APZ2_MOUSENtmt178
A2APZ3A2APZ3_MOUSENtmt1146
A0A0A6YVQ9A0A0A6YVQ9_MOUSENtmt170
A0A0A6YX97A0A0A6YX97_MOUSENtmt1144

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue118

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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