A0A0A6YXY1 · A0A0A6YXY1_MOUSE
- ProteinN-terminal Xaa-Pro-Lys N-methyltransferase 1
- GeneNtmt1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids118 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.
Catalytic activity
- N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H+
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | methyltransferase activity | |
Biological Process | N-terminal protein amino acid methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN-terminal Xaa-Pro-Lys N-methyltransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A0A6YXY1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Sequence
- Sequence statusFragment
- Length118
- Mass (Da)13,305
- Last updated2015-02-04 v1
- Checksum268A9FFD1068E72D
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8R2U4 | NTM1A_MOUSE | Ntmt1 | 223 | ||
A2APZ2 | A2APZ2_MOUSE | Ntmt1 | 78 | ||
A2APZ3 | A2APZ3_MOUSE | Ntmt1 | 146 | ||
A0A0A6YVQ9 | A0A0A6YVQ9_MOUSE | Ntmt1 | 70 | ||
A0A0A6YX97 | A0A0A6YX97_MOUSE | Ntmt1 | 144 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 118 | ||||
Keywords
- Technical term