A0A0A6YXU9 · A0A0A6YXU9_MOUSE

  • Protein
    Transforming growth factor beta
  • Gene
    Tgfb2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular space
Molecular Functionamyloid-beta binding
Molecular Functiongrowth factor activity
Molecular Functionprotein homodimerization activity
Molecular Functiontype II transforming growth factor beta receptor binding
Molecular Functiontype III transforming growth factor beta receptor binding
Biological Processcardiac epithelial to mesenchymal transition
Biological Processcardiac muscle cell proliferation
Biological Processcardioblast differentiation
Biological Processcell morphogenesis
Biological Processcell-cell junction organization
Biological Processcollagen fibril organization
Biological Processembryonic digestive tract development
Biological Processepithelial cell differentiation
Biological Processextrinsic apoptotic signaling pathway
Biological Processeye development
Biological Processglial cell migration
Biological Processhair follicle development
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of epithelial cell proliferation
Biological Processnegative regulation of macrophage cytokine production
Biological Processpositive regulation of cardioblast differentiation
Biological Processpositive regulation of cell adhesion mediated by integrin
Biological Processpositive regulation of cell division
Biological Processpositive regulation of cell growth
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of epithelial cell migration
Biological Processpositive regulation of epithelial to mesenchymal transition
Biological Processpositive regulation of heart contraction
Biological Processpositive regulation of integrin biosynthetic process
Biological Processpositive regulation of miRNA transcription
Biological Processpositive regulation of neuron apoptotic process
Biological Processpositive regulation of Notch signaling pathway
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of protein secretion
Biological Processpositive regulation of SMAD protein signal transduction
Biological Processpositive regulation of stress-activated MAPK cascade
Biological Processpositive regulation of timing of catagen
Biological Processregulation of transforming growth factor beta2 production
Biological Processresponse to hypoxia
Biological Processresponse to progesterone
Biological Processresponse to wounding
Biological Processsalivary gland morphogenesis
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transforming growth factor beta

Gene names

    • Name
      Tgfb2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    A0A0A6YXU9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501619628221-442Transforming growth factor beta
Disulfide bond337↔346
Disulfide bond345↔408
Disulfide bond374↔439
Disulfide bond378↔441
Disulfide bond407Interchain

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer; disulfide-linked.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain327-442TGF-beta family profile

Sequence similarities

Belongs to the TGF-beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    442
  • Mass (Da)
    50,462
  • Last updated
    2015-02-04 v1
  • Checksum
    1F2BC699051EFACD
MHYCVLSTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHLPSETVCPVVTTPSGSLGSFCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVQEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYASGDQKTIKSTRKKTSGKTPHLLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
P27090TGFB2_MOUSETgfb2414

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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