Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts.Liu J.T., Yao Q.P., Chen Y., Lv F., Liu Z., Bao H., Han Y., Zhang M.L., Jiang Z.L., Qi Y.X.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCTheranostics 12:4851-4865 (2022)Mapped to4
The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II.Nakatani T., Tsujimoto K., Park J., Jo T., Kimura T., Hayama Y., Konaka H., Morita T., Kato Y.[...], Kumanogoh A.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCNat Commun 12:3333-3333 (2021)Mapped to2
Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.Ying L., Zhang M., Ma X., Si Y., Li X., Su J., Yin J., Bao Y.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCFront Cell Dev Biol 9:672032-672032 (2021)Mapped to2
Loss of LAMTOR1 in pancreatic beta‑cells increases glucose‑stimulated insulin secretion in mice.Huang Q., Gong Q., Wen T., Feng S., Xu J., Liu J., Han X., Liu Q., Hu J., Zhu L.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCInt J Mol Med 45:23-32 (2020)Mapped to2
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.Li M., Zhang C.S., Zong Y., Feng J.W., Ma T., Hu M., Lin Z., Li X., Xie C.[...], Lin S.C.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCCell Metab 30:508-524.e12 (2019)Mapped to20
UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.Sun J., Liu Y., Jia Y., Hao X., Lin W.J., Tran J., Lynch G., Baudry M., Bi X.View abstractCategoriesFunction, InteractionSourceMGI: 1913758PubMedEurope PMCElife 7:0-0 (2018)Cited in4Mapped to16
Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.Hayama Y., Kimura T., Takeda Y., Nada S., Koyama S., Takamatsu H., Kang S., Ito D., Maeda Y.[...], Kumanogoh A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCJ Immunol 200:3790-3800 (2018)Mapped to18
TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.Hashimoto Y., Shirane M., Nakayama K.I.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCGenes Cells 23:418-434 (2018)Cited in8Mapped to7
Lamtor1 Is Critically Required for CD4<sup>+</sup> T Cell Proliferation and Regulatory T Cell Suppressive Function.Hosokawa T., Kimura T., Nada S., Okuno T., Ito D., Kang S., Nojima S., Yamashita K., Nakatani T.[...], Kumanogoh A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCJ Immunol 199:2008-2019 (2017)Mapped to9
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.Zhang C.S., Hawley S.A., Zong Y., Li M., Wang Z., Gray A., Ma T., Cui J., Feng J.W.[...], Lin S.C.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCNature 548:112-116 (2017)Mapped to20
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.Kimura T., Nada S., Takegahara N., Okuno T., Nojima S., Kang S., Ito D., Morimoto K., Hosokawa T.[...], Kumanogoh A.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCNat Commun 7:13130-13130 (2016)Mapped to4
Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.Yao Y., Wang J., Yoshida S., Nada S., Okada M., Inoki K.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCJ Am Soc Nephrol 27:3653-3665 (2016)Mapped to6
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.Zhang C.S., Jiang B., Li M., Zhu M., Peng Y., Zhang Y.L., Wu Y.Q., Li T.Y., Liang Y.[...], Lin S.C.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCCell Metab 20:526-540 (2014)Mapped to16
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.Koscielny G., Yaikhom G., Iyer V., Meehan T.F., Morgan H., Atienza-Herrero J., Blake A., Chen C.K., Easty R.[...], Parkinson H.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCNucleic Acids Res 42:D802-9 (2014)Mapped to99+
The lysosomal signaling anchor p18/LAMTOR1 controls epidermal development by regulating lysosome-mediated catabolic processes.Soma-Nagae T., Nada S., Kitagawa M., Takahashi Y., Mori S., Oneyama C., Okada M.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCJ Cell Sci 126:3575-3584 (2013)Mapped to2
The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes.Takahashi Y., Nada S., Mori S., Soma-Nagae T., Oneyama C., Okada M.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCBiochem Biophys Res Commun 417:1151-1157 (2012)Mapped to5
A conditional knockout resource for the genome-wide study of mouse gene function.Skarnes W.C., Rosen B., West A.P., Koutsourakis M., Bushell W., Iyer V., Mujica A.O., Thomas M., Harrow J.[...], Bradley A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCNature 474:337-342 (2011)Mapped to99+
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M.View abstractCategoriesFunctionSourceMGI: 1913758PubMedEurope PMCCell 141:290-303 (2010)Cited in12Mapped to46
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.Nada S., Hondo A., Kasai A., Koike M., Saito K., Uchiyama Y., Okada M.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 1913758PubMedEurope PMCEMBO J. 28:477-489 (2009)Cited in5Mapped to24
EUCOMM--the European conditional mouse mutagenesis program.Friedel R.H., Seisenberger C., Kaloff C., Wurst W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1913758PubMedEurope PMCBrief Funct Genomic Proteomic 6:180-185 (2007)Mapped to99+