A0A0A2A751 · A0A0A2A751_PROMR

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Binding site38Mg2+ (UniProtKB | ChEBI)
Active site67Proton acceptor
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site68substrate
Binding site146-149substrate
Binding site169substrate
Binding site174-175substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      EU96_1987

Organism names

Accessions

  • Primary accession
    A0A0A2A751

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    21,351
  • Last updated
    2015-02-04 v1
  • Checksum
    FC95B06895A4ED31
MKNLYLASKNNGKIEEYKKLLAIVNCQLLLQPETLEVEEDGLTFRDNAIKKASEVSRKTNNFSIADDSGICIEALGGKPGIYSSRYAENDKKRIERVLKELDGVQNRRAFFIANICVCSPNGEVIIESEAKCHGNIILNPRGKGGFGYDPIFEESSTRLTFAEMNNDIKDSCSHRGKALKKMIPDLIEIFS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JNAM01000014
EMBL· GenBank· DDBJ
KGF96243.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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