A0A0A1YL14 · A0A0A1YL14_9PSED

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site11-16substrate
Active site71Proton acceptor
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site72substrate
Binding site155-158substrate
Binding site178substrate
Binding site183-184substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      TMS3_0101355

Organism names

  • Taxonomic identifier
  • Strain
    • MS-3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A0A1YL14

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,188
  • Last updated
    2015-02-04 v1
  • Checksum
    1E1F53706AFB030F
MKPLSQLVLASHNAGKLKELQAMLGDAVRVRSVAEFSSVEPQETGLSFVENAILKARHAALVSGLPALADDSGLAVDFLGGAPGIYSARYADGQGDAANNAKLLEALKEVPDEQRGAQFVCALALLQHADDPLPIICEGLWHGRILHAARGEQGFGYDPLFWVEERQCSSAELAPAEKNQLSHRARAMAQLKQRLGLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AWSQ01000001
EMBL· GenBank· DDBJ
KFX70617.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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