A0A0A0QVZ6 · A0A0A0QVZ6_IPSTY
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids327 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Ips
Accessions
- Primary accessionA0A0A0QVZ6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: MSGVSSILGAINFISTIINM | ||||||
Transmembrane | 37-64 | Helical | ||||
Sequence: LFTWAVKITAVLLLLSLPVLAGAITMLL | ||||||
Transmembrane | 84-109 | Helical | ||||
Sequence: LYQHLFWFFGHPEVYILILPGFGLIS | ||||||
Transmembrane | 121-145 | Helical | ||||
Sequence: AFGVLGMIYAMTAIGLLGFVVWAHH | ||||||
Transmembrane | 157-181 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLATF | ||||||
Transmembrane | 193-213 | Helical | ||||
Sequence: LWSLGFIFLFTMGGLTGVILA | ||||||
Transmembrane | 233-251 | Helical | ||||
Sequence: YVLSMGAVFAIIAGIVQWF | ||||||
Transmembrane | 263-281 | Helical | ||||
Sequence: YLKIHFFTMFVGVNLTFFP | ||||||
Transmembrane | 301-326 | Helical | ||||
Sequence: YLLWNIISSIGSMISLISIFYFIFII |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-327 | Cytochrome oxidase subunit I profile | ||||
Sequence: IFSLHMSGVSSILGAINFISTIINMHPKGVTPEQLTLFTWAVKITAVLLLLSLPVLAGAITMLLTDRNINTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGLISHIISQESGKKEAFGVLGMIYAMTAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATFHGAQISFNPSSLWSLGFIFLFTMGGLTGVILANSSIDIILHDTYYVVAHFHYVLSMGAVFAIIAGIVQWFPLFTGLTLNKKYLKIHFFTMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYLLWNIISSIGSMISLISIFYFIFIIW |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length327
- Mass (Da)36,369
- Last updated2015-02-04 v1
- Checksum37C9C8065EFE3613
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I | ||||||
Non-terminal residue | 327 | |||||
Sequence: W |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF846139 EMBL· GenBank· DDBJ | AIT99120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846140 EMBL· GenBank· DDBJ | AIT99121.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846141 EMBL· GenBank· DDBJ | AIT99122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846142 EMBL· GenBank· DDBJ | AIT99123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846143 EMBL· GenBank· DDBJ | AIT99124.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846145 EMBL· GenBank· DDBJ | AIT99126.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846146 EMBL· GenBank· DDBJ | AIT99127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846147 EMBL· GenBank· DDBJ | AIT99128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846148 EMBL· GenBank· DDBJ | AIT99129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846149 EMBL· GenBank· DDBJ | AIT99130.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846150 EMBL· GenBank· DDBJ | AIT99131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846153 EMBL· GenBank· DDBJ | AIT99134.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846154 EMBL· GenBank· DDBJ | AIT99135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846155 EMBL· GenBank· DDBJ | AIT99136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846156 EMBL· GenBank· DDBJ | AIT99137.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846158 EMBL· GenBank· DDBJ | AIT99139.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846159 EMBL· GenBank· DDBJ | AIT99140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846161 EMBL· GenBank· DDBJ | AIT99142.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846162 EMBL· GenBank· DDBJ | AIT99143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846164 EMBL· GenBank· DDBJ | AIT99145.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846165 EMBL· GenBank· DDBJ | AIT99146.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846166 EMBL· GenBank· DDBJ | AIT99147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846167 EMBL· GenBank· DDBJ | AIT99148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846168 EMBL· GenBank· DDBJ | AIT99149.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846171 EMBL· GenBank· DDBJ | AIT99152.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846172 EMBL· GenBank· DDBJ | AIT99153.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846173 EMBL· GenBank· DDBJ | AIT99154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846174 EMBL· GenBank· DDBJ | AIT99155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846175 EMBL· GenBank· DDBJ | AIT99156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846176 EMBL· GenBank· DDBJ | AIT99157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846177 EMBL· GenBank· DDBJ | AIT99158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846178 EMBL· GenBank· DDBJ | AIT99159.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846179 EMBL· GenBank· DDBJ | AIT99160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846180 EMBL· GenBank· DDBJ | AIT99161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846181 EMBL· GenBank· DDBJ | AIT99162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846182 EMBL· GenBank· DDBJ | AIT99163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846183 EMBL· GenBank· DDBJ | AIT99164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846184 EMBL· GenBank· DDBJ | AIT99165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846185 EMBL· GenBank· DDBJ | AIT99166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846186 EMBL· GenBank· DDBJ | AIT99167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846188 EMBL· GenBank· DDBJ | AIT99169.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846189 EMBL· GenBank· DDBJ | AIT99170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846190 EMBL· GenBank· DDBJ | AIT99171.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846191 EMBL· GenBank· DDBJ | AIT99172.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846193 EMBL· GenBank· DDBJ | AIT99174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846194 EMBL· GenBank· DDBJ | AIT99175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846195 EMBL· GenBank· DDBJ | AIT99176.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846196 EMBL· GenBank· DDBJ | AIT99177.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846197 EMBL· GenBank· DDBJ | AIT99178.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846200 EMBL· GenBank· DDBJ | AIT99181.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF846201 EMBL· GenBank· DDBJ | AIT99182.1 EMBL· GenBank· DDBJ | Genomic DNA |