A0A0A0QVZ6 · A0A0A0QVZ6_IPSTY

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Ips

Accessions

  • Primary accession
    A0A0A0QVZ6

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-64Helical
Transmembrane84-109Helical
Transmembrane121-145Helical
Transmembrane157-181Helical
Transmembrane193-213Helical
Transmembrane233-251Helical
Transmembrane263-281Helical
Transmembrane301-326Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-327Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    327
  • Mass (Da)
    36,369
  • Last updated
    2015-02-04 v1
  • Checksum
    37C9C8065EFE3613
IFSLHMSGVSSILGAINFISTIINMHPKGVTPEQLTLFTWAVKITAVLLLLSLPVLAGAITMLLTDRNINTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGLISHIISQESGKKEAFGVLGMIYAMTAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATFHGAQISFNPSSLWSLGFIFLFTMGGLTGVILANSSIDIILHDTYYVVAHFHYVLSMGAVFAIIAGIVQWFPLFTGLTLNKKYLKIHFFTMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYLLWNIISSIGSMISLISIFYFIFIIW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue327

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF846139
EMBL· GenBank· DDBJ
AIT99120.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846140
EMBL· GenBank· DDBJ
AIT99121.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846141
EMBL· GenBank· DDBJ
AIT99122.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846142
EMBL· GenBank· DDBJ
AIT99123.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846143
EMBL· GenBank· DDBJ
AIT99124.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846145
EMBL· GenBank· DDBJ
AIT99126.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846146
EMBL· GenBank· DDBJ
AIT99127.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846147
EMBL· GenBank· DDBJ
AIT99128.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846148
EMBL· GenBank· DDBJ
AIT99129.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846149
EMBL· GenBank· DDBJ
AIT99130.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846150
EMBL· GenBank· DDBJ
AIT99131.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846153
EMBL· GenBank· DDBJ
AIT99134.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846154
EMBL· GenBank· DDBJ
AIT99135.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846155
EMBL· GenBank· DDBJ
AIT99136.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846156
EMBL· GenBank· DDBJ
AIT99137.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846158
EMBL· GenBank· DDBJ
AIT99139.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846159
EMBL· GenBank· DDBJ
AIT99140.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846161
EMBL· GenBank· DDBJ
AIT99142.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846162
EMBL· GenBank· DDBJ
AIT99143.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846164
EMBL· GenBank· DDBJ
AIT99145.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846165
EMBL· GenBank· DDBJ
AIT99146.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846166
EMBL· GenBank· DDBJ
AIT99147.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846167
EMBL· GenBank· DDBJ
AIT99148.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846168
EMBL· GenBank· DDBJ
AIT99149.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846171
EMBL· GenBank· DDBJ
AIT99152.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846172
EMBL· GenBank· DDBJ
AIT99153.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846173
EMBL· GenBank· DDBJ
AIT99154.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846174
EMBL· GenBank· DDBJ
AIT99155.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846175
EMBL· GenBank· DDBJ
AIT99156.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846176
EMBL· GenBank· DDBJ
AIT99157.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846177
EMBL· GenBank· DDBJ
AIT99158.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846178
EMBL· GenBank· DDBJ
AIT99159.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846179
EMBL· GenBank· DDBJ
AIT99160.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846180
EMBL· GenBank· DDBJ
AIT99161.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846181
EMBL· GenBank· DDBJ
AIT99162.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846182
EMBL· GenBank· DDBJ
AIT99163.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846183
EMBL· GenBank· DDBJ
AIT99164.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846184
EMBL· GenBank· DDBJ
AIT99165.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846185
EMBL· GenBank· DDBJ
AIT99166.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846186
EMBL· GenBank· DDBJ
AIT99167.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846188
EMBL· GenBank· DDBJ
AIT99169.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846189
EMBL· GenBank· DDBJ
AIT99170.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846190
EMBL· GenBank· DDBJ
AIT99171.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846191
EMBL· GenBank· DDBJ
AIT99172.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846193
EMBL· GenBank· DDBJ
AIT99174.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846194
EMBL· GenBank· DDBJ
AIT99175.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846195
EMBL· GenBank· DDBJ
AIT99176.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846196
EMBL· GenBank· DDBJ
AIT99177.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846197
EMBL· GenBank· DDBJ
AIT99178.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846200
EMBL· GenBank· DDBJ
AIT99181.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846201
EMBL· GenBank· DDBJ
AIT99182.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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