A0A0A0QVZ0 · A0A0A0QVZ0_IPSTY

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Scolytinae > Ips

Accessions

  • Primary accession
    A0A0A0QVZ0

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-64Helical
Transmembrane84-109Helical
Transmembrane121-145Helical
Transmembrane157-181Helical
Transmembrane193-213Helical
Transmembrane233-251Helical
Transmembrane263-281Helical
Transmembrane301-326Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-327Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    327
  • Mass (Da)
    36,382
  • Last updated
    2015-02-04 v1
  • Checksum
    6AEF3BCE48141EBD
IFSLHMSGVSSILGAINFISTIINMHPKGVNPEQLTLFTWAVKITAVLLLLSLPVLAGAITMLLTDRNINTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGLISHIISQESGKKEAFGVLGMIYAMTAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATFHGAQISFNPSSLWSLGFIFLFTMGGLTGVILANSSIDIILHDTYYVVAHFHYVLSMGAVFAIIAGIVQWFPLFTGLTLNKKYLKIHFFTMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYLLWNIISSIGSMISLISIFYFIFIIW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue327

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF846151
EMBL· GenBank· DDBJ
AIT99132.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846152
EMBL· GenBank· DDBJ
AIT99133.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846169
EMBL· GenBank· DDBJ
AIT99150.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846170
EMBL· GenBank· DDBJ
AIT99151.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846187
EMBL· GenBank· DDBJ
AIT99168.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846198
EMBL· GenBank· DDBJ
AIT99179.1
EMBL· GenBank· DDBJ
Genomic DNA
KF846203
EMBL· GenBank· DDBJ
AIT99184.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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