A0A0A0MSA1 · A0A0A0MSA1_HUMAN
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- GeneCACNA1C
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2173 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | perikaryon | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | T-tubule | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A0A0MSA1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane, sarcolemma ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 128-145 | Helical | ||||
Sequence: IIILLTIFANCVALAIYI | ||||||
Transmembrane | 165-185 | Helical | ||||
Sequence: LFLIIFTVEAFLKVIAYGLLF | ||||||
Transmembrane | 197-215 | Helical | ||||
Sequence: LLDFIIVVVGLFSAILEQA | ||||||
Transmembrane | 268-290 | Helical | ||||
Sequence: LLHIALLVLFVIIIYAIIGLELF | ||||||
Transmembrane | 349-370 | Helical | ||||
Sequence: FAFAMLTVFQCITMEGWTDVLY | ||||||
Transmembrane | 382-404 | Helical | ||||
Sequence: WVYFVSLVIFGSFFVLNLVLGVL | ||||||
Transmembrane | 525-543 | Helical | ||||
Sequence: VFYWLVIFLVFLNTLTIAS | ||||||
Transmembrane | 651-673 | Helical | ||||
Sequence: IASLLLLLFLFIIIFSLLGMQLF | ||||||
Transmembrane | 727-753 | Helical | ||||
Sequence: MLVCIYFIILFICGNYILLNVFLAIAV | ||||||
Transmembrane | 901-920 | Helical | ||||
Sequence: IFTNLILFFILLSSISLAAE | ||||||
Transmembrane | 932-954 | Helical | ||||
Sequence: ILFYFDIVFTTIFTIEIALKMTA | ||||||
Transmembrane | 974-997 | Helical | ||||
Sequence: LLVVSVSLISFGIQSSAINVVKIL | ||||||
Transmembrane | 1018-1051 | Helical | ||||
Sequence: VVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLF | ||||||
Transmembrane | 1143-1169 | Helical | ||||
Sequence: SIFFIIYIIIIAFFMMNIFVGFVIVTF | ||||||
Transmembrane | 1220-1237 | Helical | ||||
Sequence: YFEYLMFVLILLNTICLA | ||||||
Transmembrane | 1249-1271 | Helical | ||||
Sequence: IAMNILNMLFTGLFTVEMILKLI | ||||||
Transmembrane | 1359-1382 | Helical | ||||
Sequence: ALPYVALLIVMLFFIYAVIGMQVF | ||||||
Transmembrane | 1452-1476 | Helical | ||||
Sequence: AVFYFISFYMLCAFLIINLFVAVIM |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4,325 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for disulfide bond, glycosylation, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Disulfide bond | 298↔326 | UniProt | |||||
Sequence: CYNQEGIADVPAEDDPSPCALETGHGRQC | |||||||
Disulfide bond | 316↔332 | UniProt | |||||
Sequence: CALETGHGRQCQNGTVC | |||||||
Glycosylation | 328 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 815 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Disulfide bond | 1058↔1069 | UniProt | |||||
Sequence: CSDSSKQTEAEC | |||||||
Disulfide bond | 1431↔1447 | UniProt | |||||
Sequence: CAPESEPSNSTEGETPC | |||||||
Modified residue (large scale data) | 1670 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MVNENTRMYIPEENHQGSNY | ||||||
Region | 73-98 | Disordered | ||||
Sequence: ISTVSSTQRKRQQYGKPKKQGSTTAT | ||||||
Region | 449-481 | Disordered | ||||
Sequence: PENEDEGMDEEKPRNMSMPTSETESVNTENVAG | ||||||
Compositional bias | 764-809 | Basic and acidic residues | ||||
Sequence: SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSI | ||||||
Region | 764-861 | Disordered | ||||
Sequence: SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRP | ||||||
Domain | 1610-1644 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPS | ||||||
Compositional bias | 1730-1775 | Polar residues | ||||
Sequence: INKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTAL | ||||||
Region | 1730-1799 | Disordered | ||||
Sequence: INKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLS | ||||||
Region | 1981-2015 | Disordered | ||||
Sequence: ASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESS | ||||||
Compositional bias | 1984-2001 | Pro residues | ||||
Sequence: PRPFATPPATPGSRGWPP | ||||||
Region | 2138-2173 | Disordered | ||||
Sequence: AGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL | ||||||
Compositional bias | 2140-2164 | Basic and acidic residues | ||||
Sequence: QDRAGGEEDAGCVRARGRPSEEELQ |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,173
- Mass (Da)243,661
- Last updated2015-01-07 v1
- Checksum93EDA1BC5CF0E7C5
Computationally mapped potential isoform sequences
There are 19 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q13936 | CAC1C_HUMAN | CACNA1C | 2221 | ||
A0AA34QVT1 | A0AA34QVT1_HUMAN | CACNA1C | 255 | ||
A0A804HHT8 | A0A804HHT8_HUMAN | CACNA1C | 351 | ||
A0A804HI37 | A0A804HI37_HUMAN | CACNA1C | 2168 | ||
A0A804HIR0 | A0A804HIR0_HUMAN | CACNA1C | 2251 | ||
A0A804HIZ0 | A0A804HIZ0_HUMAN | CACNA1C | 2138 | ||
A0A804HIJ8 | A0A804HIJ8_HUMAN | CACNA1C | 2168 | ||
A0A5F9ZHD9 | A0A5F9ZHD9_HUMAN | CACNA1C | 125 | ||
A0A804HJR1 | A0A804HJR1_HUMAN | CACNA1C | 2168 | ||
A0A804HJB6 | A0A804HJB6_HUMAN | CACNA1C | 2168 | ||
A0A0A0MR67 | A0A0A0MR67_HUMAN | CACNA1C | 2173 | ||
A0A804HKE9 | A0A804HKE9_HUMAN | CACNA1C | 2152 | ||
A0A804HKC4 | A0A804HKC4_HUMAN | CACNA1C | 2193 | ||
E9PDI6 | E9PDI6_HUMAN | CACNA1C | 2198 | ||
F5GY28 | F5GY28_HUMAN | CACNA1C | 2209 | ||
A0A087WUX4 | A0A087WUX4_HUMAN | CACNA1C | 462 | ||
F5H522 | F5H522_HUMAN | CACNA1C | 2163 | ||
F5H638 | F5H638_HUMAN | CACNA1C | 371 | ||
Q5V9X8 | Q5V9X8_HUMAN | CACNA1C | 225 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 764-809 | Basic and acidic residues | ||||
Sequence: SAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSI | ||||||
Compositional bias | 1730-1775 | Polar residues | ||||
Sequence: INKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTAL | ||||||
Compositional bias | 1984-2001 | Pro residues | ||||
Sequence: PRPFATPPATPGSRGWPP | ||||||
Compositional bias | 2140-2164 | Basic and acidic residues | ||||
Sequence: QDRAGGEEDAGCVRARGRPSEEELQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005293 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005342 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005344 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005414 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC005866 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC006051 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455573 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455574 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |