A0A0A0MSA1 · A0A0A0MSA1_HUMAN

  • Protein
    Voltage-dependent L-type calcium channel subunit alpha
  • Gene
    CACNA1C
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Features

Showing features for binding site.

121732004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site363Ca2+ (UniProtKB | ChEBI)
Binding site706Ca2+ (UniProtKB | ChEBI)
Binding site1115Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentperikaryon
Cellular Componentpostsynaptic density membrane
Cellular ComponentT-tubule
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      CACNA1C

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A0A0MSA1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane, sarcolemma
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Cell projection, dendrite
Membrane
; Multi-pass membrane protein
Perikaryon
Postsynaptic density membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane128-145Helical
Transmembrane165-185Helical
Transmembrane197-215Helical
Transmembrane268-290Helical
Transmembrane349-370Helical
Transmembrane382-404Helical
Transmembrane525-543Helical
Transmembrane651-673Helical
Transmembrane727-753Helical
Transmembrane901-920Helical
Transmembrane932-954Helical
Transmembrane974-997Helical
Transmembrane1018-1051Helical
Transmembrane1143-1169Helical
Transmembrane1220-1237Helical
Transmembrane1249-1271Helical
Transmembrane1359-1382Helical
Transmembrane1452-1476Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4,325 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for disulfide bond, glycosylation, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Disulfide bond298↔326UniProt
Disulfide bond316↔332UniProt
Glycosylation328UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)815PRIDEPhosphoserine
Disulfide bond1058↔1069UniProt
Disulfide bond1431↔1447UniProt
Modified residue (large scale data)1670PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-20Disordered
Region73-98Disordered
Region449-481Disordered
Compositional bias764-809Basic and acidic residues
Region764-861Disordered
Domain1610-1644Voltage-dependent calcium channel alpha-1 subunit IQ
Compositional bias1730-1775Polar residues
Region1730-1799Disordered
Region1981-2015Disordered
Compositional bias1984-2001Pro residues
Region2138-2173Disordered
Compositional bias2140-2164Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,173
  • Mass (Da)
    243,661
  • Last updated
    2015-01-07 v1
  • Checksum
    93EDA1BC5CF0E7C5
MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAGTQAHCLLLRRANPSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFHLECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL

Computationally mapped potential isoform sequences

There are 19 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q13936CAC1C_HUMANCACNA1C2221
A0AA34QVT1A0AA34QVT1_HUMANCACNA1C255
A0A804HHT8A0A804HHT8_HUMANCACNA1C351
A0A804HI37A0A804HI37_HUMANCACNA1C2168
A0A804HIR0A0A804HIR0_HUMANCACNA1C2251
A0A804HIZ0A0A804HIZ0_HUMANCACNA1C2138
A0A804HIJ8A0A804HIJ8_HUMANCACNA1C2168
A0A5F9ZHD9A0A5F9ZHD9_HUMANCACNA1C125
A0A804HJR1A0A804HJR1_HUMANCACNA1C2168
A0A804HJB6A0A804HJB6_HUMANCACNA1C2168
A0A0A0MR67A0A0A0MR67_HUMANCACNA1C2173
A0A804HKE9A0A804HKE9_HUMANCACNA1C2152
A0A804HKC4A0A804HKC4_HUMANCACNA1C2193
E9PDI6E9PDI6_HUMANCACNA1C2198
F5GY28F5GY28_HUMANCACNA1C2209
A0A087WUX4A0A087WUX4_HUMANCACNA1C462
F5H522F5H522_HUMANCACNA1C2163
F5H638F5H638_HUMANCACNA1C371
Q5V9X8Q5V9X8_HUMANCACNA1C225

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias764-809Basic and acidic residues
Compositional bias1730-1775Polar residues
Compositional bias1984-2001Pro residues
Compositional bias2140-2164Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005293
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005342
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005344
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005414
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005866
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC006051
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF455573
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF455574
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp