A0A0A0MR25 · A0A0A0MR25_HUMAN
- ProteinFibroblast growth factor receptor
- GeneFGFR2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids821 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 487-493 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGEGCFG | ||||||
Binding site | 517 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 565-567 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYA | ||||||
Binding site | 571 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 626 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 630 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 644 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | fibroblast growth factor receptor activity | |
Biological Process | positive regulation of cell population proliferation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibroblast growth factor receptor
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A0A0MR25
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 380-400 | Helical | ||||
Sequence: IAIYCIGVFLIACMVVTVILC |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3,558 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MVSWGRFICLVVVTMATLSLA | ||||||
Chain | PRO_5001974407 | 22-821 | Fibroblast growth factor receptor | |||
Sequence: RPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVFAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT | ||||||
Disulfide bond | 62↔107 | |||||
Sequence: CLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYAC | ||||||
Glycosylation | 83 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 123 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 179↔231 | |||||
Sequence: CPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTC | ||||||
Glycosylation | 228 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 241 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 265 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 278↔344 | |||||
Sequence: CKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVFAAGVNTTDKEIEVLYIRNVTFEDAGEYTC | ||||||
Glycosylation | 297 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 320 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 333 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 39-125 | Ig-like | ||||
Sequence: PTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVT | ||||||
Region | 131-151 | Disordered | ||||
Sequence: GDDEDDTDGAEDFVSENSNNK | ||||||
Domain | 154-247 | Ig-like | ||||
Sequence: PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLD | ||||||
Domain | 256-360 | Ig-like | ||||
Sequence: PILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVFAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLT | ||||||
Domain | 481-770 | Protein kinase | ||||
Sequence: LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYL |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length821
- Mass (Da)92,071
- Last updated2015-01-07 v1
- Checksum58F3A4B9D44F2828
Computationally mapped potential isoform sequences
There are 15 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P21802 | FGFR2_HUMAN | FGFR2 | 821 | ||
E7EVR7 | E7EVR7_HUMAN | FGFR2 | 707 | ||
A0A5S6RJB7 | A0A5S6RJB7_HUMAN | FGFR2 | 768 | ||
A0A1B0GWF4 | A0A1B0GWF4_HUMAN | FGFR2 | 144 | ||
A0A1W2PQT9 | A0A1W2PQT9_HUMAN | FGFR2 | 429 | ||
A0A804HI10 | A0A804HI10_HUMAN | FGFR2 | 137 | ||
A0A804HI76 | A0A804HI76_HUMAN | FGFR2 | 670 | ||
A0A804HIH8 | A0A804HIH8_HUMAN | FGFR2 | 153 | ||
H7BXU9 | H7BXU9_HUMAN | FGFR2 | 669 | ||
H7C265 | H7C265_HUMAN | FGFR2 | 371 | ||
S4R381 | S4R381_HUMAN | FGFR2 | 593 | ||
S4R3B2 | S4R3B2_HUMAN | FGFR2 | 251 | ||
A0A087X2D1 | A0A087X2D1_HUMAN | FGFR2 | 64 | ||
A0A087WY21 | A0A087WY21_HUMAN | FGFR2 | 136 | ||
D2CGD1 | D2CGD1_HUMAN | FGFR2 | 732 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC009988 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455288 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |