Kmt2d mutants demonstrate psychomotor and behavior impairments such as hypotonia fine motor coordination and hyperactivity. Kmt2d mutant mouse is new model for Kabuki Syndrome.
MLL4 suppresses medulloblastoma by establishing superenhancers and broad H3K4me3 to activate multiple mechanisms that lead to activation of tumor suppressor genes and repression of oncogenes.
results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.