A0A0A0EU91 · A0A0A0EU91_9GAMM
- ProteinPimeloyl-[acyl-carrier protein] methyl ester esterase
- GenebioH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Catalytic activity
- 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + methanol + H+
Pathway
Cofactor biosynthesis; biotin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 18 | substrate | ||||
Sequence: W | ||||||
Active site | 78 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 78-79 | substrate | ||||
Sequence: SL | ||||||
Active site | 204 | |||||
Sequence: D | ||||||
Active site | 232 | |||||
Sequence: H | ||||||
Binding site | 232 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pimelyl-[acyl-carrier protein] methyl ester esterase activity | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePimeloyl-[acyl-carrier protein] methyl ester esterase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Lysobacter
Accessions
- Primary accessionA0A0A0EU91
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-236 | AB hydrolase-1 | ||||
Sequence: ALGLIHGWAMHGGLFTPLVDRLAEHYTLHLVDLPGHGHARDDDRALEPVALARALVARVPDAVWLGWSLGGQVALRAALDHPDRVRGLVMLAASPRFVRSDDWPHGVGSALFSDFGDALQRDFRGTLDGFLALEALGSSSAQDELRKLRAQAFERGEPSPRALLEGLRLLDTLDLRAELPGLQLPSLWLSGRRDRLVPAGAMPAAAALAPQSRSVVIANAGHAPFL |
Sequence similarities
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)27,681
- Last updated2015-01-07 v1
- Checksum7B840707C4F1ECEF
Keywords
- Technical term