A0A0A0EJC9 · A0A0A0EJC9_9GAMM
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids538 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2O
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Lysobacter
Accessions
- Primary accessionA0A0A0EJC9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 36-55 | Helical | ||||
Sequence: LYLLFSFTMFIIGGAFSVVI | ||||||
Transmembrane | 75-96 | Helical | ||||
Sequence: MTSMHALVMIFGGVMPAFVGLA | ||||||
Transmembrane | 117-138 | Helical | ||||
Sequence: WSFWILPFAFIMLLGTLFLPGG | ||||||
Transmembrane | 158-186 | Helical | ||||
Sequence: VAFQIFAIHMMGVSSIMGAINVIATVLNM | ||||||
Transmembrane | 198-225 | Helical | ||||
Sequence: IFTWTWLITAFLLIAVMPVLAGAVTMLL | ||||||
Transmembrane | 245-269 | Helical | ||||
Sequence: MYQHIFWFFGHPEVYIMILPAFGIV | ||||||
Transmembrane | 281-305 | Helical | ||||
Sequence: LFGYQAMVYATTAIAFLSFIVWAHH | ||||||
Transmembrane | 317-339 | Helical | ||||
Sequence: LFFMYATMLISIPTGVKIFNWVT | ||||||
Transmembrane | 351-375 | Helical | ||||
Sequence: PMLFSVAFVILFTIGGFSGLMLAIV | ||||||
Transmembrane | 387-411 | Helical | ||||
Sequence: VVAHFHYVLVTGSVLALISAVYYWW | ||||||
Transmembrane | 423-444 | Helical | ||||
Sequence: WGKFHFWWTMVFVNLLFFPQHF | ||||||
Transmembrane | 464-486 | Helical | ||||
Sequence: WNLVSSIGAFGMFLTPFMMIVIL |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 24-527 | Cytochrome oxidase subunit I profile | ||||
Sequence: WLLSTNHKDIGTLYLLFSFTMFIIGGAFSVVIRSELAQPGLQFVDPQFFNQMTSMHALVMIFGGVMPAFVGLANWMIPLQIGAPDMALPRMNNWSFWILPFAFIMLLGTLFLPGGAMGGGWTMYPPLSLQGGSNVAFQIFAIHMMGVSSIMGAINVIATVLNMRAPGMDLMKMPIFTWTWLITAFLLIAVMPVLAGAVTMLLTDKFFATSFFNAAGGGDPVMYQHIFWFFGHPEVYIMILPAFGIVSEVIPTYSRKPLFGYQAMVYATTAIAFLSFIVWAHHMFTAGMPLGGELFFMYATMLISIPTGVKIFNWVTTMWRGSLTFETPMLFSVAFVILFTIGGFSGLMLAIVPADFQYHDTYFVVAHFHYVLVTGSVLALISAVYYWWPKWTGRMYNEAWGKFHFWWTMVFVNLLFFPQHFLGLAGMPRRIPDYNVVFADWNLVSSIGAFGMFLTPFMMIVILGHSKKYGAKAEARAWEGARGLEWTVPSPAPHHTFTVPPVIH |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length538
- Mass (Da)60,237
- Last updated2015-01-07 v1
- ChecksumEE183AFB9021470F
Keywords
- Technical term