A0A099YX54 · A0A099YX54_TINGU

Function

function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Hormone biosynthesis; thyroid hormone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site458Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionheme binding
Molecular Functioniodide peroxidase activity
Biological Processhormone biosynthetic process
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress
Biological Processthyroid hormone generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thyroid peroxidase
  • EC number

Gene names

    • ORF names
      N309_08261

Organism names

  • Taxonomic identifier
  • Strain
    • BGI_N309
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Palaeognathae > Tinamiformes > Tinamidae > Tinamus

Accessions

  • Primary accession
    A0A099YX54

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

PTM/Processing

Keywords

Interaction

Subunit

Interacts with DUOX1, DUOX2 and CYBA.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain704-760Sushi
Domain760-803EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    811
  • Mass (Da)
    90,980
  • Last updated
    2015-01-07 v1
  • Checksum
    318984E1E646C14F
EETEDSCIIEAIQKDSNLLNYAGQYTSKRHIEGKGIATPTLLLAFSKSPEQESQVISQAAERMEMSMQVLKQKVCQKRKRSLHPTDLLSADLLTMIANISGCLPYMLPPKCPNNCLANKYRLITGACNNRWGSSNTALARWLPPSYEDGLGQPRGWNPDALYNGVPLPPVREVTRKIIHASNEAVTEDNLYSDIIMVWGQYIDHDIAFTPQSTSRTTFLSGAECQMTCEKENPCFPIQVTTNDTLSKGMDCLPFYRSSPACGTGDHSTLFGNLTALNPRQQINGLTTFLDASTVYGSTPAAENKIRNLTSEEGLLRINLKYDDNNREYLPFVDLIPSPCAQDPNASDSKRVECFLAGESRSNEVISLAAMHTLWLREHNRLARALKSINRHWSPETVYQEARKIVGALHQIITLRDYIPKIIGPDAFNQYIGVYRGYDPTINPTISNIFSTAAFRFGHATIQPIVKRLNAQYLDDPELPNLLLHEVFFSPWRLIKEGGLDPLLRGLLAHSAKLQVQDQLLNEELTEKLFVLSNNSTLDLASLNLQRGRDHGLPGYNDWREFCGLPKLETEADLNTIISNQQVTEKIMELYHNPNNIDVWLGGLVEDFLPSARTGPLFACIIGKQMKALRDGDRFWWENDNVFTEAQKHELRKHSLSRVICENTGISEVPVDAFQLGKFPADFEHCDNIPGMNLEAWQENYQKEETCGTPKNVENGDFVYCSEFGKSAVIYSCQYGFQLQGEEQLTCTSKGWDFQAPVCIDINECENEVTPPCSSTAKCINTKGSYQCLCTDPYKLAEDGRTCIGNAHEPTV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue811

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KL886583
EMBL· GenBank· DDBJ
KGL74022.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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