A0A099YX54 · A0A099YX54_TINGU
- ProteinThyroid peroxidase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids811 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.
Catalytic activity
- 2 H+ + H2O2 + 2 iodide = diiodine + 2 H2O
Cofactor
Pathway
Hormone biosynthesis; thyroid hormone biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | heme binding | |
Molecular Function | iodide peroxidase activity | |
Biological Process | hormone biosynthetic process | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress | |
Biological Process | thyroid hormone generation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThyroid peroxidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Palaeognathae > Tinamiformes > Tinamidae > Tinamus
Accessions
- Primary accessionA0A099YX54
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
PTM/Processing
Keywords
- PTM
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 704-760 | Sushi | ||||
Sequence: ETCGTPKNVENGDFVYCSEFGKSAVIYSCQYGFQLQGEEQLTCTSKGWDFQAPVCID | ||||||
Domain | 760-803 | EGF-like | ||||
Sequence: DINECENEVTPPCSSTAKCINTKGSYQCLCTDPYKLAEDGRTCI |
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length811
- Mass (Da)90,980
- Last updated2015-01-07 v1
- Checksum318984E1E646C14F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E | ||||||
Non-terminal residue | 811 | |||||
Sequence: V |
Keywords
- Technical term