A0A099J4G9 · A0A099J4G9_9MICO

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site67Proton acceptor
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site68substrate
Binding site150-153substrate
Binding site173substrate
Binding site178-179substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      BJ997_002368
      , GY21_15385

Organism names

  • Taxonomic identifier
  • Strains
    • RuG17
    • DSM 21065
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Cryobacterium

Accessions

  • Primary accession
    A0A099J4G9

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    20,908
  • Last updated
    2015-01-07 v1
  • Checksum
    3C62C75CA378405D
MQIVLATHNQHKVDELRRILAPQLVGVEVLAYDGPEPVENGATFTENALIKARAAAAHTGLPAIADDSGICVDVLGGSPGIFSARWAGPSKDAEENLRLLLWQVSDIADDHRGAHFTCAAALVLPDGTERTVVGEWPGQLLHEPNGANGFGYDPIFLPDGYAISAAELSAHVKNQVSHRAIAFESLLPLVREVLGAP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPXF01000073
EMBL· GenBank· DDBJ
KGJ72422.1
EMBL· GenBank· DDBJ
Genomic DNA
JACHBQ010000001
EMBL· GenBank· DDBJ
MBB5641820.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help