A0A099J2I1 · A0A099J2I1_9MICO
- ProteinAdenosylhomocysteinase
- GeneahcY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 64 | substrate | ||||
Sequence: T | ||||||
Binding site | 156 | substrate | ||||
Sequence: D | ||||||
Binding site | 218 | substrate | ||||
Sequence: E | ||||||
Binding site | 219-221 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TTT | ||||||
Binding site | 248 | substrate | ||||
Sequence: K | ||||||
Binding site | 252 | substrate | ||||
Sequence: D | ||||||
Binding site | 253 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 282-287 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GYGDVG | ||||||
Binding site | 284-289 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GDVGKG | ||||||
Binding site | 305 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 310 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 340 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 409 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 416 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | L-homocysteine biosynthetic process | |
Biological Process | one-carbon metabolic process | |
Biological Process | S-adenosylmethionine cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Cryobacterium
Accessions
- Primary accessionA0A099J2I1
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 253-415 | S-adenosyl-L-homocysteine hydrolase NAD binding | ||||
Sequence: NKYGIRHSLPDGLNRATDVLIGGKVVFVAGYGDVGKGAAEALKGQGARVIVSEIDPINALQAAMDGFQVAKLESVVEDVDIFVSGTGNFNVIRTEHMLRMKHLAIIANVGHFDNEIDMAALEVLPGATKVQIKPQVDEWRLPSGRSILVLSEGRLMNLGNATG |
Sequence similarities
Belongs to the adenosylhomocysteinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)53,317
- Last updated2015-01-07 v1
- ChecksumAEEDAD24D9EA85D2
Keywords
- Technical term