A0A098Z3V5 · A0A098Z3V5_STREE
- ProteinRibosomal RNA small subunit methyltransferase A
- GenersmA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids290 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Catalytic activity
- adenosine1518/adenosine1519 in 16S rRNA + 4 S-adenosyl-L-methionine = N6-dimethyladenosine1518/N6-dimethyladenosine1519 in 16S rRNA + 4 S-adenosyl-L-homocysteine + 4 H+
RHEA-COMP:10232 CHEBI:74411 Position: 1518CHEBI:74411 Position: 1519+ 4 CHEBI:59789 = RHEA-COMP:10233 CHEBI:74493 Position: 1518CHEBI:74493 Position: 1519+ 4 CHEBI:57856 + 4 CHEBI:15378
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 27 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 29 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 54 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 75 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 100 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 125 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity | |
Molecular Function | RNA binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal RNA small subunit methyltransferase A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA0A098Z3V5
Proteomes
Subcellular Location
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-210 | Ribosomal RNA adenine methylase transferase N-terminal | ||||
Sequence: ILQKIVDTAEIDDQVNVIEIGPGIGALTEFLAERAAQVMAFEIDHRLVPILADTLRDFDNVTVVNEDILKVDLAQHIQNFKNPNLPIKVVANLPYYITTPILMHLIESGIPFSEFVVMMQKEVADRISAQPNTKAYGSLSIAVQYYMTAKVAFIVPRTVFVPAPNVDSAILKMVRRP |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length290
- Mass (Da)32,220
- Last updated2015-01-07 v1
- Checksum95B9E2FD0A397FAF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CKLF01000008 EMBL· GenBank· DDBJ | CIV18518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CKRE01000007 EMBL· GenBank· DDBJ | CIY74670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAVPGZ010000234 EMBL· GenBank· DDBJ | MDS8039808.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHQ01000025 EMBL· GenBank· DDBJ | MTV72594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNHX01000008 EMBL· GenBank· DDBJ | MTV86498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR216040 EMBL· GenBank· DDBJ | VFH96668.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAAXWD010000004 EMBL· GenBank· DDBJ | VQD05259.1 EMBL· GenBank· DDBJ | Genomic DNA |