A0A098E171 · CHRY3_GIBZE

Function

function

Oxidoreductase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398).
Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable)

Pathway

Pigment biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionoxidoreductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidoreductase chry3
  • EC number
  • Alternative names
    • Chrysogine biosynthesis cluster protein 3

Gene names

    • Name
      chry3
    • ORF names
      FG11397, FGRAMPH1_01T21963

Organism names

Accessions

  • Primary accession
    A0A098E171
  • Secondary accessions
    • A0A0E0SN27

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004501741-379Oxidoreductase chry3

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-23Disordered
Region126-150Disordered

Sequence similarities

Belongs to the asaB hydroxylase/desaturase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    42,272
  • Last updated
    2015-01-07 v1
  • Checksum
    8B563DAE25F81303
MTTATKPHQGRFRYLTRGSQPTPSKEAYLLPSLSEFGDIVTLPLTDLRPSLDLGQDSPYKLDVHGFTARRHDSALHSAPYSRASWNNEKLLRQIYFPEVEEFVKNVTGCKKAVVSAAVVRNRLYSEGDDSAPAEEEADTQASSSDDTSHMFPPIFGNSVKDGVCPAPKVHLDCTPKGARHHIRRYHSEVALAAEKVIEAENRLLESGVEWNDLKDHSGKVPHFALFSIWRPLKTVHRDPLALSSAASFPVSDYVPCDQREPTDHSIPSHLYRIVGRDDENIDKNDDTYQTQSYLAYAPRDAEKTSHAWHYISEQQPSDVLVIQLFDNEMEGHARAPLEGGKGKSDLGVGGAVHSAFELVDQDEDAEARESIEVRVAAFW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HG970334
EMBL· GenBank· DDBJ
CEF87840.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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