A0A098E171 · CHRY3_GIBZE
- ProteinOxidoreductase chry3
- Genechry3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids379 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Oxidoreductase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398).
Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable)
Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable)
Pathway
Pigment biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | oxidoreductase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxidoreductase chry3
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium
Accessions
- Primary accessionA0A098E171
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000450174 | 1-379 | Oxidoreductase chry3 | |||
Sequence: MTTATKPHQGRFRYLTRGSQPTPSKEAYLLPSLSEFGDIVTLPLTDLRPSLDLGQDSPYKLDVHGFTARRHDSALHSAPYSRASWNNEKLLRQIYFPEVEEFVKNVTGCKKAVVSAAVVRNRLYSEGDDSAPAEEEADTQASSSDDTSHMFPPIFGNSVKDGVCPAPKVHLDCTPKGARHHIRRYHSEVALAAEKVIEAENRLLESGVEWNDLKDHSGKVPHFALFSIWRPLKTVHRDPLALSSAASFPVSDYVPCDQREPTDHSIPSHLYRIVGRDDENIDKNDDTYQTQSYLAYAPRDAEKTSHAWHYISEQQPSDVLVIQLFDNEMEGHARAPLEGGKGKSDLGVGGAVHSAFELVDQDEDAEARESIEVRVAAFW |
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MTTATKPHQGRFRYLTRGSQPTP | ||||||
Region | 126-150 | Disordered | ||||
Sequence: EGDDSAPAEEEADTQASSSDDTSHM |
Sequence similarities
Belongs to the asaB hydroxylase/desaturase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length379
- Mass (Da)42,272
- Last updated2015-01-07 v1
- Checksum8B563DAE25F81303
Keywords
- Technical term