A0A097QH86 · A0A097QH86_9ROSA
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-19 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GLAVMG | ||||||
Binding site | 37-39 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: NRT | ||||||
Binding site | 81-83 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: VKA | ||||||
Binding site | 109 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 109 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: N | ||||||
Binding site | 135-137 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: SGG | ||||||
Active site | 189 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 192-193 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: HN | ||||||
Active site | 196 | Proton donor | ||||
Sequence: E | ||||||
Binding site | 197 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: Y | ||||||
Binding site | 267 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: K | ||||||
Binding site | 294 | substrate; ligand shared between dimeric partners; in other chain | ||||
Sequence: R | ||||||
Binding site | 459 | substrate; ligand shared between dimeric partners | ||||
Sequence: R | ||||||
Binding site | 465 | substrate; ligand shared between dimeric partners | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate 2-dehydrogenase activity | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate catabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Rosaceae > Amygdaloideae > Amygdaleae > Prunus
Accessions
- Primary accessionA0A097QH86
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 185-481 | 6-phosphogluconate dehydrogenase C-terminal | ||||
Sequence: GNFVKMVHNGIEYGDMQLISEAYDVLKNVGGLSNEELGEIFAEWNKGELESFLIEITADIFKVRDDLADGFLVDKLLDKTGMKGTGKWTVQQAAELSVAAPTIAASLDCRYLSGLKEEREKAEEALKQAGFKEEIGSVTSGIDKKRLIDDVRQALYASKICSYAQGMNLLRAKSVEKGWGLNLGELARIWKGGCIIRAVFLDRIKNAYQRNQSLPNLIVDPDFAKEMVQRHAAWRRVVGLAVSAGISTPGMCASLSYFDTYRRGRLPANLVQAQRDLFGAHTYERVDRPGAFHTEWT |
Sequence similarities
Belongs to the 6-phosphogluconate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length495
- Mass (Da)53,834
- Last updated2015-01-07 v1
- Checksum962070FFFA92C63E