A0A097QH86 · A0A097QH86_9ROSA

  • Protein
    6-phosphogluconate dehydrogenase, decarboxylating
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

149550100150200250300350400450
TypeIDPosition(s)Description
Binding site14-19NADP+ (UniProtKB | ChEBI)
Binding site37-39NADP+ (UniProtKB | ChEBI)
Binding site81-83NADP+ (UniProtKB | ChEBI)
Binding site109NADP+ (UniProtKB | ChEBI)
Binding site109substrate; ligand shared between dimeric partners; in other chain
Binding site135-137substrate; ligand shared between dimeric partners; in other chain
Active site189Proton acceptor
Binding site192-193substrate; ligand shared between dimeric partners; in other chain
Active site196Proton donor
Binding site197substrate; ligand shared between dimeric partners; in other chain
Binding site267substrate; ligand shared between dimeric partners; in other chain
Binding site294substrate; ligand shared between dimeric partners; in other chain
Binding site459substrate; ligand shared between dimeric partners
Binding site465substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionphosphogluconate 2-dehydrogenase activity
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate catabolic process
Biological Processpentose-phosphate shunt, oxidative branch

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Rosaceae > Amygdaloideae > Amygdaleae > Prunus

Accessions

  • Primary accession
    A0A097QH86

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain185-4816-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    495
  • Mass (Da)
    53,834
  • Last updated
    2015-01-07 v1
  • Checksum
    962070FFFA92C63E
MEASPALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVDRAHNEGNLPLFGQYNPRDFVLSIQRPRSVIILVKAGAPVDQTIAALSAHMEPGDAIIDGGNEWYENTERRIAEATGRGLLYLGMGVSGGEEGARHGPSLMPGGSHQAYTNVQDILHKVAAQVEDGPCVTYIGEGGSGNFVKMVHNGIEYGDMQLISEAYDVLKNVGGLSNEELGEIFAEWNKGELESFLIEITADIFKVRDDLADGFLVDKLLDKTGMKGTGKWTVQQAAELSVAAPTIAASLDCRYLSGLKEEREKAEEALKQAGFKEEIGSVTSGIDKKRLIDDVRQALYASKICSYAQGMNLLRAKSVEKGWGLNLGELARIWKGGCIIRAVFLDRIKNAYQRNQSLPNLIVDPDFAKEMVQRHAAWRRVVGLAVSAGISTPGMCASLSYFDTYRRGRLPANLVQAQRDLFGAHTYERVDRPGAFHTEWTKLAQKSGSSVGALN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM214672
EMBL· GenBank· DDBJ
AIU64845.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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