A0A097IWB3 · A0A097IWB3_9ADEN
- ProteinPre-histone-like nucleoprotein
- GeneL2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids188 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
Miscellaneous
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 23-24 | Cleavage; by viral protease | ||||
Sequence: GA |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell | |
Cellular Component | host cell nucleolus | |
Cellular Component | viral capsid | |
Molecular Function | DNA binding | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral penetration into host nucleus |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePre-histone-like nucleoprotein
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Simian mastadenovirus H > simian adenovirus 54
Accessions
- Primary accessionA0A097IWB3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Histone-like nucleoprotein
Note: Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.
Pre-histone-like nucleoprotein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine; by host | ||||
Sequence: S | ||||||
Chain | PRO_5023569049 | 2-188 | Pre-histone-like nucleoprotein | |||
Sequence: SILISPSNNTGWGLGVNKMYGGAKHRSNQHPVRVRGHYRAPWGAYSRNRRPAERTTVDDVIDSVVADARNYNSPAAASPSTVDAVIDSVVADARAYARQKRRSRRARRSLSRPTAAMQAARNLLRRARRTSRRALTRQIRAGRNRRRAAVQAAAAIARLATPQRGNVYWVRDASGVRVPVRTRPPRV | ||||||
Chain | PRO_5023569048 | 24-188 | Histone-like nucleoprotein | |||
Sequence: AKHRSNQHPVRVRGHYRAPWGAYSRNRRPAERTTVDDVIDSVVADARNYNSPAAASPSTVDAVIDSVVADARAYARQKRRSRRARRSLSRPTAAMQAARNLLRRARRTSRRALTRQIRAGRNRRRAAVQAAAAIARLATPQRGNVYWVRDASGVRVPVRTRPPRV |
Post-translational modification
Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
Keywords
- PTM
Expression
Induction
Expressed in the late phase of the viral replicative cycle.
Keywords
- Developmental stage
Interaction
Subunit
Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
Structure
Sequence
- Sequence statusComplete
- Length188
- Mass (Da)20,954
- Last updated2015-01-07 v1
- Checksum382AB57F44F98E1C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A097IWC0 | A0A097IWC0_9ADEN | L2 | 486 | ||
A0A097IW72 | A0A097IW72_9ADEN | L2 | 341 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KM190146 EMBL· GenBank· DDBJ | AIT70978.1 EMBL· GenBank· DDBJ | Genomic DNA |