A0A097IWB3 · A0A097IWB3_9ADEN

  • Protein
    Pre-histone-like nucleoprotein
  • Gene
    L2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

118820406080100120140160180
TypeIDPosition(s)Description
Site23-24Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleolus
Cellular Componentviral capsid
Molecular FunctionDNA binding
Biological Processsymbiont entry into host cell
Biological Processviral penetration into host nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-histone-like nucleoprotein
  • Alternative names
    • Pre-core protein VII
      (pVII
      )
  • Cleaved into 1 chains
    • Histone-like nucleoprotein
      (NP
      ) Alternative names: Core protein VII

Gene names

    • Name
      L2

Organism names

  • Taxonomic identifier
  • Strain
    • 23336
  • Taxonomic lineage
    Viruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Simian mastadenovirus H > simian adenovirus 54

Accessions

  • Primary accession
    A0A097IWB3

Proteomes

Subcellular Location

Histone-like nucleoprotein

Virion
Note: Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.

Pre-histone-like nucleoprotein

Host nucleus, host nucleolus

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine; by host
ChainPRO_50235690492-188Pre-histone-like nucleoprotein
ChainPRO_502356904824-188Histone-like nucleoprotein

Post-translational modification

Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region98-119Disordered

Sequence similarities

Belongs to the adenoviridae histone-like nucleoprotein family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    20,954
  • Last updated
    2015-01-07 v1
  • Checksum
    382AB57F44F98E1C
MSILISPSNNTGWGLGVNKMYGGAKHRSNQHPVRVRGHYRAPWGAYSRNRRPAERTTVDDVIDSVVADARNYNSPAAASPSTVDAVIDSVVADARAYARQKRRSRRARRSLSRPTAAMQAARNLLRRARRTSRRALTRQIRAGRNRRRAAVQAAAAIARLATPQRGNVYWVRDASGVRVPVRTRPPRV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A097IWC0A0A097IWC0_9ADENL2486
A0A097IW72A0A097IW72_9ADENL2341

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM190146
EMBL· GenBank· DDBJ
AIT70978.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp