A0A097EN91 · A0A097EN91_9GAMM

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site122(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site126-128(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site229Plays an important role in substrate specificity
Binding site355-357(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionmethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processmethylation
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      LO80_02925

Organism names

Accessions

  • Primary accession
    A0A097EN91

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue230N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-385Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    417
  • Mass (Da)
    45,384
  • Last updated
    2015-01-07 v1
  • Checksum
    47B9B6D3CF30AED5
MFSFEKNSLKNTDKEVFDAIELEVKRQHEHVELIASENYASPAVMEAQGSQLTNKYAEGYHGKRYYGGCEFVDIVEKLAVERAQELFGVDYANVQPHSGSQANAAVYNAVLKPGDTVLGMDLGAGGHLTHGSKVNFSGKIYNSIQYGLDENGDIDYNQVAKLAKEHKPKMIIAGFSAFSGIIKWEKFREIADSIDAVLMADIAHVAGLVAAGVYPNPFPYVDVATTTTHKTLRGPRGGLILCNNNPDLAKKFQSAIFPGIQGGPLMHVIAAKAVAFKEALEPSFTEYQKQVLKNAKAMEKVLKERNINIISGGTNNHLLLLDITNTGFSGKEAEAALGRANITVNKNSIPNDPRSPFVTSGLRIGSPAITTRGFKEKECEQVANLLADVVFNCGDSNIENKIATEILKLCNNFPVYN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP009574
EMBL· GenBank· DDBJ
AIT09030.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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