A0A097C4K6 · A0A097C4K6_9CUCU

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 126_append
    • 130_append
    • 135_append
    • 136_append
    • 137_append
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Chrysomeloidea > Chrysomelidae > Donaciinae > Macroplea

Accessions

  • Primary accession
    A0A097C4K6

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane37-67Helical
Transmembrane88-110Helical
Transmembrane130-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,964
  • Last updated
    2015-01-07 v1
  • Checksum
    3AE18D8E2F799A39
TLYFIFGAWSSMMGTSLSILIRSELSTPGSLIENDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLIPLMLGAPDMAFPRMNNMSFWLLPPAITFLMMSSITENGAGTGWTVYPPLSSNIAHSGTSVDLAIFSLHLAGISSILGAINFISTILNMRPIGMKMDKMPLFVWAVMITAILLLLSLPVLAGAITMLLTDRNINTTFFDPMGGGDPILYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ962152
EMBL· GenBank· DDBJ
AIS77068.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ964851
EMBL· GenBank· DDBJ
AIS79767.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494509
EMBL· GenBank· DDBJ
AWS33998.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494510
EMBL· GenBank· DDBJ
AWS33999.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494523
EMBL· GenBank· DDBJ
AWS34011.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494565
EMBL· GenBank· DDBJ
AWS34049.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494568
EMBL· GenBank· DDBJ
AWS34052.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494572
EMBL· GenBank· DDBJ
AWS34056.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494573
EMBL· GenBank· DDBJ
AWS34057.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494574
EMBL· GenBank· DDBJ
AWS34058.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494576
EMBL· GenBank· DDBJ
AWS34060.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494578
EMBL· GenBank· DDBJ
AWS34062.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494580
EMBL· GenBank· DDBJ
AWS34064.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494581
EMBL· GenBank· DDBJ
AWS34065.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494604
EMBL· GenBank· DDBJ
AWS34088.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494607
EMBL· GenBank· DDBJ
AWS34091.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494609
EMBL· GenBank· DDBJ
AWS34093.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494612
EMBL· GenBank· DDBJ
AWS34096.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494622
EMBL· GenBank· DDBJ
AWS34105.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494624
EMBL· GenBank· DDBJ
AWS34107.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494625
EMBL· GenBank· DDBJ
AWS34108.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494632
EMBL· GenBank· DDBJ
AWS34115.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494633
EMBL· GenBank· DDBJ
AWS34116.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494635
EMBL· GenBank· DDBJ
AWS34118.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494638
EMBL· GenBank· DDBJ
AWS34121.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494639
EMBL· GenBank· DDBJ
AWS34122.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494645
EMBL· GenBank· DDBJ
AWS34128.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494653
EMBL· GenBank· DDBJ
AWS34136.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494664
EMBL· GenBank· DDBJ
AWS34147.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494665
EMBL· GenBank· DDBJ
AWS34148.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494670
EMBL· GenBank· DDBJ
AWS34153.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494671
EMBL· GenBank· DDBJ
AWS34154.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494672
EMBL· GenBank· DDBJ
AWS34155.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494677
EMBL· GenBank· DDBJ
AWS34160.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494692
EMBL· GenBank· DDBJ
AWS34175.1
EMBL· GenBank· DDBJ
Genomic DNA
MG494693
EMBL· GenBank· DDBJ
AWS34176.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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