A0A097C4K6 · A0A097C4K6_9CUCU
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids219 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Chrysomeloidea > Chrysomelidae > Donaciinae > Macroplea
Accessions
- Primary accessionA0A097C4K6
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 37-67 | Helical | |||
Transmembrane | 88-110 | Helical | |||
Transmembrane | 130-155 | Helical | |||
Transmembrane | 167-194 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Sequence
- Sequence statusFragment
- Length219
- Mass (Da)23,964
- Last updated2015-01-07 v1
- Checksum3AE18D8E2F799A39
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 219 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ962152 EMBL· GenBank· DDBJ | AIS77068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ964851 EMBL· GenBank· DDBJ | AIS79767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494509 EMBL· GenBank· DDBJ | AWS33998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494510 EMBL· GenBank· DDBJ | AWS33999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494523 EMBL· GenBank· DDBJ | AWS34011.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494565 EMBL· GenBank· DDBJ | AWS34049.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494568 EMBL· GenBank· DDBJ | AWS34052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494572 EMBL· GenBank· DDBJ | AWS34056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494573 EMBL· GenBank· DDBJ | AWS34057.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494574 EMBL· GenBank· DDBJ | AWS34058.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494576 EMBL· GenBank· DDBJ | AWS34060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494578 EMBL· GenBank· DDBJ | AWS34062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494580 EMBL· GenBank· DDBJ | AWS34064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494581 EMBL· GenBank· DDBJ | AWS34065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494604 EMBL· GenBank· DDBJ | AWS34088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494607 EMBL· GenBank· DDBJ | AWS34091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494609 EMBL· GenBank· DDBJ | AWS34093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494612 EMBL· GenBank· DDBJ | AWS34096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494622 EMBL· GenBank· DDBJ | AWS34105.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494624 EMBL· GenBank· DDBJ | AWS34107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494625 EMBL· GenBank· DDBJ | AWS34108.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494632 EMBL· GenBank· DDBJ | AWS34115.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494633 EMBL· GenBank· DDBJ | AWS34116.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494635 EMBL· GenBank· DDBJ | AWS34118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494638 EMBL· GenBank· DDBJ | AWS34121.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494639 EMBL· GenBank· DDBJ | AWS34122.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494645 EMBL· GenBank· DDBJ | AWS34128.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494653 EMBL· GenBank· DDBJ | AWS34136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494664 EMBL· GenBank· DDBJ | AWS34147.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494665 EMBL· GenBank· DDBJ | AWS34148.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494670 EMBL· GenBank· DDBJ | AWS34153.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494671 EMBL· GenBank· DDBJ | AWS34154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494672 EMBL· GenBank· DDBJ | AWS34155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494677 EMBL· GenBank· DDBJ | AWS34160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494692 EMBL· GenBank· DDBJ | AWS34175.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG494693 EMBL· GenBank· DDBJ | AWS34176.1 EMBL· GenBank· DDBJ | Genomic DNA |