A0A097C3P9 · A0A097C3P9_PLASE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Chrysomeloidea > Chrysomelidae > Donaciinae > Plateumaris

Accessions

  • Primary accession
    A0A097C3P9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-59Helical
Transmembrane93-113Helical
Transmembrane133-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-219Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    219
  • Mass (Da)
    23,772
  • Last updated
    2015-01-07 v1
  • Checksum
    BA946C2EA3064898
TLYFIFGAWSGMMGTSLSMLIRTELMNPGSLIGNDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLIPLMLGAPDMAFPRMNNMSFWLLPPSLTFLIMSSIVENGAGTGWTVYPPLSSNIAHSGASVDLAIFSLHLAGVSSILGAVNFITTIINMRPMGMKMDKVPLFAWAVMITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPVLYQHLF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue219

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ961834
EMBL· GenBank· DDBJ
AIS76750.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ963041
EMBL· GenBank· DDBJ
AIS77957.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ965199
EMBL· GenBank· DDBJ
AIS80115.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ966700
EMBL· GenBank· DDBJ
AIS81616.1
EMBL· GenBank· DDBJ
Genomic DNA
KM448518
EMBL· GenBank· DDBJ
AJB94233.1
EMBL· GenBank· DDBJ
Genomic DNA
KU915214
EMBL· GenBank· DDBJ
ARB61634.1
EMBL· GenBank· DDBJ
Genomic DNA
KU916008
EMBL· GenBank· DDBJ
ARB62428.1
EMBL· GenBank· DDBJ
Genomic DNA
MZ629515
EMBL· GenBank· DDBJ
UDU90684.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp