A0A096NBT6 · A0A096NBT6_PAPAN

  • Protein
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
  • Gene
    PLCG2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

function

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentintracellular vesicle
Cellular Componentmembrane raft
Cellular Componentperinuclear region of cytoplasm
Cellular Componentruffle membrane
Molecular Functionphosphatidylinositol phospholipase C activity
Molecular Functionphosphorylation-dependent protein binding
Molecular Functionphosphotyrosine residue binding
Molecular Functionprotein tyrosine kinase binding
Molecular Functionscaffold protein binding
Biological Processantifungal innate immune response
Biological ProcessB cell receptor signaling pathway
Biological Processcalcium-mediated signaling
Biological Processcellular response to calcium ion
Biological Processfollicular B cell differentiation
Biological Processinositol trisphosphate biosynthetic process
Biological Processlipopolysaccharide-mediated signaling pathway
Biological Processmacrophage activation involved in immune response
Biological Processnegative regulation of programmed cell death
Biological Processphosphatidylinositol biosynthetic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processphospholipid catabolic process
Biological Processpositive regulation of calcium-mediated signaling
Biological Processpositive regulation of dendritic cell cytokine production
Biological Processpositive regulation of epithelial cell migration
Biological Processpositive regulation of I-kappaB phosphorylation
Biological Processpositive regulation of interleukin-10 production
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of interleukin-2 production
Biological Processpositive regulation of interleukin-23 production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of macrophage cytokine production
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of neuroinflammatory response
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of NLRP3 inflammasome complex assembly
Biological Processpositive regulation of peptidyl-tyrosine phosphorylation
Biological Processpositive regulation of phagocytosis, engulfment
Biological Processpositive regulation of reactive oxygen species biosynthetic process
Biological Processpositive regulation of receptor internalization
Biological Processpositive regulation of tumor necrosis factor production
Biological Processpositive regulation of type I interferon production
Biological Processprogrammed cell death
Biological Processregulation of calcineurin-NFAT signaling cascade
Biological Processregulation of canonical NF-kappaB signal transduction
Biological Processregulation of lipid metabolic process
Biological Processrelease of sequestered calcium ion into cytosol
Biological Processresponse to axon injury
Biological Processresponse to yeast
Biological Processstimulatory C-type lectin receptor signaling pathway
Biological ProcessT cell receptor signaling pathway
Biological Processtoll-like receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
  • EC number

Gene names

    • Name
      PLCG2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Papio

Accessions

  • Primary accession
    A0A096NBT6

Proteomes

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-131PH
Domain532-635SH2
Domain646-735SH2
Domain769-829SH3
Domain930-1044PI-PLC Y-box
Domain1038-1169C2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,265
  • Mass (Da)
    147,872
  • Last updated
    2022-05-25 v2
  • Checksum
    13A6C34283E2E804
MSTMVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDALNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTVLPLINFKVSSAKFLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLLHEQQEHWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIKEHAFVTSSFPVILSIEEHCSVEQQRHMAKTFKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTTEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYESLSRGEAEDMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSITRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKFMQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGADYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLKEKRVSNSKFYS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5R1P2A0A8I5R1P2_PAPANPLCG21217

Keywords

Genome annotation databases

Similar Proteins

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