A0A096MS22 · A0A096MS22_PAPAN

Function

Catalytic activity

  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H+
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+
    This reaction proceeds in the forward direction.
  • N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    EC:3.1.1.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site50Ca2+ (UniProtKB | ChEBI)
Binding site52Ca2+ (UniProtKB | ChEBI)
Binding site54Ca2+ (UniProtKB | ChEBI)
Active site70
Binding site71Ca2+ (UniProtKB | ChEBI)
Active site121

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular space
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functionsignaling receptor binding
Biological Processantibacterial humoral response
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processarachidonic acid secretion
Biological Processdefense response to Gram-positive bacterium
Biological Processfatty acid biosynthetic process
Biological Processinnate immune response in mucosa
Biological Processlipid catabolic process
Biological Processphosphatidylcholine metabolic process
Biological Processphosphatidylglycerol metabolic process
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of podocyte apoptotic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2
  • EC number

Gene names

    • Name
      PLA2G1B

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Papio

Accessions

  • Primary accession
    A0A096MS22

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_501285916616-148Phospholipase A2
Disulfide bond51↔67
Disulfide bond66↔127
Disulfide bond73↔120
Disulfide bond83↔113
Disulfide bond106↔118

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-147Phospholipase A2

Sequence similarities

Belongs to the phospholipase A2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    148
  • Mass (Da)
    16,493
  • Last updated
    2014-11-26 v1
  • Checksum
    6AED24485ED24F1F
MKLLVLAVLLTVAAAESGISSRAVWQFRKLIKCVIPGSDPYLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLSSCKFLLDNPYTHTYSYSCSNSEITCSSKNKECEAFICNCDRNAAICFSKAPYNKEHKNLDSKKYCQS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I3LUE2A0A2I3LUE2_PAPANPLA2G1B70

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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