A0A096MS22 · A0A096MS22_PAPAN
- ProteinPhospholipase A2
- GenePLA2G1B
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids148 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+This reaction proceeds in the forward direction.
- 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H+
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
- N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H+This reaction proceeds in the forward direction.
- N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipase A2 activity | |
Molecular Function | phospholipid binding | |
Molecular Function | signaling receptor binding | |
Biological Process | antibacterial humoral response | |
Biological Process | antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | arachidonic acid secretion | |
Biological Process | defense response to Gram-positive bacterium | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | innate immune response in mucosa | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylcholine metabolic process | |
Biological Process | phosphatidylglycerol metabolic process | |
Biological Process | positive regulation of fibroblast proliferation | |
Biological Process | positive regulation of podocyte apoptotic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipase A2
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Papio
Accessions
- Primary accessionA0A096MS22
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MKLLVLAVLLTVAAA | ||||||
Chain | PRO_5012859166 | 16-148 | Phospholipase A2 | |||
Sequence: ESGISSRAVWQFRKLIKCVIPGSDPYLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLSSCKFLLDNPYTHTYSYSCSNSEITCSSKNKECEAFICNCDRNAAICFSKAPYNKEHKNLDSKKYCQS | ||||||
Disulfide bond | 51↔67 | |||||
Sequence: CGLGGSGTPVDELDKCC | ||||||
Disulfide bond | 66↔127 | |||||
Sequence: CCQTHDNCYDQAKKLSSCKFLLDNPYTHTYSYSCSNSEITCSSKNKECEAFICNCDRNAAIC | ||||||
Disulfide bond | 73↔120 | |||||
Sequence: CYDQAKKLSSCKFLLDNPYTHTYSYSCSNSEITCSSKNKECEAFICNC | ||||||
Disulfide bond | 83↔113 | |||||
Sequence: CKFLLDNPYTHTYSYSCSNSEITCSSKNKEC | ||||||
Disulfide bond | 106↔118 | |||||
Sequence: CSSKNKECEAFIC |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-147 | Phospholipase A2 | ||||
Sequence: AVWQFRKLIKCVIPGSDPYLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLSSCKFLLDNPYTHTYSYSCSNSEITCSSKNKECEAFICNCDRNAAICFSKAPYNKEHKNLDSKKYCQ |
Sequence similarities
Belongs to the phospholipase A2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length148
- Mass (Da)16,493
- Last updated2014-11-26 v1
- Checksum6AED24485ED24F1F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I3LUE2 | A0A2I3LUE2_PAPAN | PLA2G1B | 70 |
Keywords
- Technical term