A0A096LNH6 · A0A096LNH6_HUMAN
- ProteinDedicator of cytokinesis 1
- GeneDOCK1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1886 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nuclear speck | |
Cellular Component | nucleoplasm | |
Molecular Function | guanyl-nucleotide exchange factor activity | |
Biological Process | cell migration | |
Biological Process | hematopoietic progenitor cell differentiation | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A096LNH6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,660 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 1702 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1725 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1764 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1772 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1777 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1779 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1788 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1793 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1832 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 1844 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1846 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1865 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1879 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-70 | SH3 | ||||
Sequence: REEKYGVAFYNYDARGADELSLQIGDTVHILETYEGWYRGYTLRKKSKKGIFPASYIHLKEA | ||||||
Coiled coil | 185-212 | |||||
Sequence: FRAHEIASKQVEERLQEEKSQKQNIDIN | ||||||
Domain | 446-630 | C2 DOCK-type | ||||
Sequence: RNDIYVTLVQGDFDKGSKTTAKNVEVTVSVYDEDGKRLEHVIFPGAGDEAISEYKSVIYYQVKQPRWFETVKVAIPIEDVNRSHLRFTFRHRSSQDSKDKSEKIFALAFVKLMRYDGTTLRDGEHDLIVYKAEAKKLEDAATYLSLPSTKAELEEKGHSATGKSMQSLGSCTISKDSFQISTLVC | ||||||
Domain | 1228-1638 | DOCKER | ||||
Sequence: YKEIEREEMYIRYLYKLCDLHKECDNYTEAAYTLLLHAKLLKWSEDVCVAHLTQRDGYQATTQGQLKEQLYQEIIHYFDKGKMWEEAIALGKELAEQYENEMFDYEQLSELLKKQAQFYENIVKVIRPKPDYFAVGYYGQGFPTFLRGKVFIYRGKEYERREDFEARLLTQFPNAEKMKTTSPPGDDIKNSPGQYIQCFTVKPKLDLPPKFHRPVSEQIVSFYRVNEVQRFEYSRPIRKGEKNPDNEFANMWIERTIYTTAYKLPGILRWFEVKSVFMVEISPLENAIETMQLTNDKINSMVQQHLDDPSLPINPLSMLLNGIVDPAVMGGFANYEKAFFTDRYLQEHPEAHEKIEKLKDLIAWQIPFLAEGIRIHGDKVTEALRPFHERMEACFKQLKEKVEKEYGVRIM | ||||||
Region | 1640-1737 | Disordered | ||||
Sequence: SSLDDRRGSRPRSMVRSFTMPSSSRPLSVASVSSLSSDSTPSRPGSDGFALEPLLPKKMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFKP | ||||||
Compositional bias | 1654-1683 | Polar residues | ||||
Sequence: VRSFTMPSSSRPLSVASVSSLSSDSTPSRP | ||||||
Compositional bias | 1697-1736 | Basic and acidic residues | ||||
Sequence: KMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFK | ||||||
Compositional bias | 1753-1783 | Polar residues | ||||
Sequence: TISPLRPQRPKSQVMNVIGSERRFSVSPSSP | ||||||
Region | 1753-1886 | Disordered | ||||
Sequence: TISPLRPQRPKSQVMNVIGSERRFSVSPSSPSSQQTPPPVTPRAKLSFSMQSSLELNGMTGADVADVPPPLPLKGSVADYGNLMENQDLLGSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTTRKQASVDSGIVQ | ||||||
Compositional bias | 1791-1810 | Polar residues | ||||
Sequence: PVTPRAKLSFSMQSSLELNG | ||||||
Compositional bias | 1843-1874 | Pro residues | ||||
Sequence: GSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTT |
Sequence similarities
Belongs to the DOCK family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,886
- Mass (Da)217,753
- Last updated2014-11-26 v1
- Checksum4FF4A899AE5EA98A
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q14185 | DOCK1_HUMAN | DOCK1 | 1865 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1654-1683 | Polar residues | ||||
Sequence: VRSFTMPSSSRPLSVASVSSLSSDSTPSRP | ||||||
Compositional bias | 1697-1736 | Basic and acidic residues | ||||
Sequence: KMHSRSQDKLDKDDLEKEKKDKKKEKRNSKHQEIFEKEFK | ||||||
Compositional bias | 1753-1783 | Polar residues | ||||
Sequence: TISPLRPQRPKSQVMNVIGSERRFSVSPSSP | ||||||
Compositional bias | 1791-1810 | Polar residues | ||||
Sequence: PVTPRAKLSFSMQSSLELNG | ||||||
Compositional bias | 1843-1874 | Pro residues | ||||
Sequence: GSPTPPPPPPHQRHLPPPLPSKTPPPPPPKTT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL359094 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL390920 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL607029 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL772134 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AUXG01000230 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX470155 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX470201 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FP565175 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FP565787 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455291 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |