A0A095AUH2 · A0A095AUH2_SCHHA

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

147850100150200250300350400450
Type
IDPosition(s)Description
Binding site10-15NADP+ (UniProtKB | ChEBI)
Binding site33-35NADP+ (UniProtKB | ChEBI)
Binding site75-77NADP+ (UniProtKB | ChEBI)
Binding site103NADP+ (UniProtKB | ChEBI)
Binding site103substrate; ligand shared between dimeric partners; in other chain
Binding site129-131substrate; ligand shared between dimeric partners; in other chain
Active site184Proton acceptor
Binding site187-188substrate; ligand shared between dimeric partners; in other chain
Active site191Proton donor
Binding site192substrate; ligand shared between dimeric partners; in other chain
Binding site261substrate; ligand shared between dimeric partners; in other chain
Binding site288substrate; ligand shared between dimeric partners; in other chain
Binding site451substrate; ligand shared between dimeric partners
Binding site457substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate metabolic process
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • ORF names
      MS3_06507

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    A0A095AUH2

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain180-4746-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    52,805
  • Last updated
    2014-11-26 v1
  • MD5 Checksum
    18313100D7026543E6E73E0A3859D024
MARADIGMIGLAVMGQNLVLNMNDHGFTISVYNRTVSKVKEFIENEAKGTNIIGTMSLEEFVQSLKRPRKAMLLVKAGQAVDDFISKLVPLLEKGDIIIDGGNSEYMDTDRRCSELAKQGILYVGTGVSGGEEGARHGPSLMPGGNPEAWPHIKPIFQAIAAKAKSGEPCCDWTGPAGSGHYVKMVHNGIEYADMQLIAEAYHLLRYLGHFQNDGIAQVFKEWNEGPLESYLIEITSHIFNYRNPDGSYLIDQILDAAGQKGTGKWTAICGLDHGVPVTLIAEAVFSRQLSSMRTLRSEACRVLNTTPDKPFCCSSPEIAKKLIDDIWKALYASKIVSYAQGFMLLQQAYQAFGWKLDLGAIALMWRGGCIIRSKFLGNIKEAYDKNPNLSNLLLDPFFKKVIDQCEDGWRRVVSHGALNAIPTPVFSSALSFYDGIKCPHLPSNLIQAQRDYFGAHQFEKTDNPGTFIHVDWTGCDI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KL250975
EMBL· GenBank· DDBJ
KGB38136.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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