A0A095AUH2 · A0A095AUH2_SCHHA
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids478 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10-15 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 33-35 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 75-77 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 103 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 103 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 129-131 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 184 | Proton acceptor | |||
Binding site | 187-188 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 191 | Proton donor | |||
Binding site | 192 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 261 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 288 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 451 | substrate; ligand shared between dimeric partners | |||
Binding site | 457 | substrate; ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate metabolic process | |
Biological Process | pentose-phosphate shunt |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma
Accessions
- Primary accessionA0A095AUH2
Interaction
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)52,805
- Last updated2014-11-26 v1
- MD5 Checksum18313100D7026543E6E73E0A3859D024
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KL250975 EMBL· GenBank· DDBJ | KGB38136.1 EMBL· GenBank· DDBJ | Genomic DNA |