A0A095ARH4 · A0A095ARH4_SCHHA

Function

function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site18-24GTP (UniProtKB | ChEBI)
Active site19Proton acceptor
Binding site19Mg2+ (UniProtKB | ChEBI)
Binding site19-22IMP (UniProtKB | ChEBI)
Active site31Proton donor
Binding site108IMP (UniProtKB | ChEBI)
Active site119
Binding site122IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site201IMP (UniProtKB | ChEBI)
Binding site216IMP (UniProtKB | ChEBI)
Binding site276-282substrate
Binding site280IMP (UniProtKB | ChEBI)
Binding site282GTP (UniProtKB | ChEBI)
Binding site308-310GTP (UniProtKB | ChEBI)
Binding site392-394GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process
Biological ProcessIMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • ORF names
      MS3_05283

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    A0A095ARH4

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    44,332
  • Last updated
    2014-11-26 v1
  • Checksum
    856A8F36616E5D3D
MTKSAEGLVSVVLGAQWGDEGKGKLVDLLSHTVVAGGQEYFFHLLPSGIVNPNVLAVIGNGVVVNLQALFQEIDEAVGKGLLDVASRLRISDRCHLEELRGVNSLGTTKKGIGPTYSSKVTRNGLRVCDLMGDWVQFTAKYRELVNYVKRRYPKLETSVEQSLEQLKTYRQKLSGMVCDSVTLINKLVESKQANILVEGAQSCMLDIDFGTYPHVTSSNCSVGGVCTGLGLSPSRVGPVYGVIKAYTTRVGSGTFPTELLDGIGEFIQKKGCEWGVTTKRKRRIGWLDTVVIRYAHIINDFNALALTKIDVLDDLEEVKIAKAYVDPETGCELDSFPSDSSVLNRVVVVYETLPGWKTSTHGCRVYEKLPTAAKVFVETVEKLLNIPIRWIGTGASRDSIIIRSV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KL250830
EMBL· GenBank· DDBJ
KGB36971.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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