A0A095AEX1 · A0A095AEX1_SCHHA

Function

function

UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionglycosyltransferase activity
Molecular FunctionUDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
  • EC number
  • Alternative names
    • GlcNAc-1-P transferase
    • N-acetylglucosamine-1-phosphate transferase

Gene names

    • ORF names
      MS3_00550

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma

Accessions

  • Primary accession
    A0A095AEX1

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-38Helical
Transmembrane72-93Helical
Transmembrane105-124Helical
Transmembrane136-165Helical
Transmembrane177-197Helical
Transmembrane209-235Helical
Transmembrane241-263Helical
Transmembrane395-418Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region329-361Disordered
Compositional bias341-355Basic and acidic residues

Sequence similarities

Belongs to the glycosyltransferase 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    423
  • Mass (Da)
    47,134
  • Last updated
    2014-11-26 v1
  • Checksum
    3AC3D0D8716CED69
MESTCASTNEGHLLSTYRHFFELLVLVCMSIFGAKYVLKLFKKYKGEFLRAGFAGVDMNKPSKPTLPEAQGVICGVVFLSIMFLFIPVPFWRYLVGKADAQSLEFIQFLAGLLSICCMLFLGFADDALNLPWRHKIGFPFVAGLPLLMVYLANEGTTSIAVPVMLRNALGSSVDIGILYYIYMGLLTVFCTNSINIYAGVNGLEVGQAIVIGASLILFNLIELSSMTFAVVGILGHFSKTLLLFFLPQIVNFLYSTPQLFGLIPCPRHRLPRYDPADGLLHPSRVRFHPKSLSRPGQFVLTVFSYVGIIECKLCPDCIPNISTSPTTGMIVSQSSHENMSSDEEQTSERQRARSRSPAQTKLPTEEIVEVDNLTVINMMLRVLGPRNEQQTTNTLLLLQILCSCFAFMIRYPLAWLFYDVPAK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias341-355Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KL250502
EMBL· GenBank· DDBJ
KGB32396.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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