A0A094ZYA1 · A0A094ZYA1_SCHHA
- ProteinSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids416 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Catalytic activity
- succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 53 | ATP (UniProtKB | ChEBI) | |||
Binding site | 60-62 | ATP (UniProtKB | ChEBI) | |||
Binding site | 121 | ATP (UniProtKB | ChEBI) | |||
Binding site | 211 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 225 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 276 | substrate; ligand shared with subunit alpha | |||
Binding site | 333-335 | substrate; ligand shared with subunit alpha | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | succinate-CoA ligase complex | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | succinate-CoA ligase (ADP-forming) activity | |
Biological Process | succinyl-CoA metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Strigeidida > Schistosomatoidea > Schistosomatidae > Schistosoma
Accessions
- Primary accessionA0A094ZYA1
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-214 | ATP-grasp fold succinyl-CoA synthetase-type | |||
Domain | 274-393 | ATP-citrate synthase/succinyl-CoA ligase C-terminal | |||
Sequence similarities
Belongs to the succinate/malate CoA ligase beta subunit family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)45,335
- Last updated2014-11-26 v1
- Checksum865951D2B7C1C699
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KL251183 EMBL· GenBank· DDBJ | KGB39342.1 EMBL· GenBank· DDBJ | Genomic DNA |