A0A094HKY5 · A0A094HKY5_9PEZI
- ProteinInosine triphosphate pyrophosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids649 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Catalytic activity
- ITP + H2O = IMP + diphosphate + H+
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 468-473 | ITP (UniProtKB | ChEBI) | |||
Binding site | 496 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 508 | ITP (UniProtKB | ChEBI) | |||
Binding site | 524 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 524-525 | ITP (UniProtKB | ChEBI) | |||
Binding site | 600-603 | ITP (UniProtKB | ChEBI) | |||
Binding site | 623 | ITP (UniProtKB | ChEBI) | |||
Binding site | 628-629 | ITP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | dITP diphosphatase activity | |
Molecular Function | ITP diphosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | XTP diphosphatase activity | |
Biological Process | deoxyribonucleoside triphosphate catabolic process | |
Biological Process | nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine triphosphate pyrophosphatase
- EC number
- Short namesITPase ; Inosine triphosphatase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Thelebolales > Thelebolaceae > Pseudogymnoascus
Accessions
- Primary accessionA0A094HKY5
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-27 | C2H2-type | |||
Domain | 63-86 | C2H2-type | |||
Region | 88-142 | Disordered | |||
Sequence similarities
Belongs to the HAM1 NTPase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length649
- Mass (Da)71,895
- Last updated2014-11-26 v1
- MD5 Checksum223A58A2F19CBC068C75BF8C46323F42
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JPKD01000850 EMBL· GenBank· DDBJ | KFZ16090.1 EMBL· GenBank· DDBJ | Genomic DNA |