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A0A094HKY5 · A0A094HKY5_9PEZI

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site468-473ITP (UniProtKB | ChEBI)
Binding site496Mg2+ (UniProtKB | ChEBI)
Binding site508ITP (UniProtKB | ChEBI)
Binding site524Mg2+ (UniProtKB | ChEBI)
Binding site524-525ITP (UniProtKB | ChEBI)
Binding site600-603ITP (UniProtKB | ChEBI)
Binding site623ITP (UniProtKB | ChEBI)
Binding site628-629ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      V501_02405

Organism names

Accessions

  • Primary accession
    A0A094HKY5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain4-27C2H2-type
Domain63-86C2H2-type
Region88-142Disordered

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    649
  • Mass (Da)
    71,895
  • Last updated
    2014-11-26 v1
  • MD5 Checksum
    223A58A2F19CBC068C75BF8C46323F42
MAGASCPFCGYEAKTEYDILYHMEDLHSEGNSPFIPTDAHPVDATQEGHPSRSSQAMEDVGYVECPISECGETVPMAELDGHLELHSMEDSDRDSHVDSPAWKWEGATEPADSKFDTSLPTALRNLDEGSDPPLLSAADRQSKAKESWRGILNMPKSIVTPHVATKSKSGKGRLGTAELGPHAYEDKMPAWLHNLLLSDGMPRTTTKLNSSGGIKTVKKIGNYVPGVLPVLETLIEQDPDTEYAYTCHPSVEHVSKLKNEGGFCGYRNIQMLTSYIVNNRSQGCYHFKEKMPTIFQIQEFIEHAWDVGINTVGRAETGGIIGTRKYIGTPEAQAMLRSLDIDCDAQAFKTDGKLAADEILMKNVEEYFRASGVDSTSKIRRTQLPPIYFQHPGHSMTIVGIEKKLDGSKNLLVFDPMFHDAPDVIKLIGRTSFSVKNPAEFLRAYRRNMKYLKKYRAFEVLSQLNFITGNKHKLAEVQAILGDAVDLQSRSIDLVEIQGTIEEISKDKCRRAAEEVQGPVLVEDTALIFNAFKNLPGPYIKWFFESLGHDGLNKLLAGFEDKSAESVCTFAYSEGPGHEPIIFQGRTEGKIVPARGAIAFGWDPIFEYGPAGQTYAEMPKAEKNKISHRGKALEKLKAWLLEAVDSSKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPKD01000850
EMBL· GenBank· DDBJ
KFZ16090.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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