A0A093YRV0 · A0A093YRV0_9PEZI
- ProteinGlutathione hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids577 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
Catalytic activity
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Pathway
Sulfur metabolism; glutathione metabolism.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 112 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Active site | 387 | Nucleophile | ||||
Sequence: T | ||||||
Binding site | 405-407 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: TVN | ||||||
Binding site | 429 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 457-458 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: SS | ||||||
Binding site | 480 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | glutathione hydrolase activity | |
Molecular Function | leukotriene C4 gamma-glutamyl transferase activity | |
Biological Process | glutathione catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione hydrolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Leotiomycetes incertae sedis > Pseudeurotiaceae > Pseudogymnoascus
Accessions
- Primary accessionA0A093YRV0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-36 | |||||
Sequence: MHGFLGQANPGRSSNTRWRFALLSLLALLPPPSVEA | ||||||
Chain | PRO_5001889653 | 37-577 | Glutathione hydrolase | |||
Sequence: SIVLSRDGTRGAVASESSICSNIGIDLIRRGGNAADAAVGTTLCVGVIGMYHSGIGGGGFMLVRSETGEYEDVDFRETAPSAAYEDMYANFTIGSIVGGDASGVPGELRGFEYLHKKYGKLPWAMVVMPAAKVAERGFTVTEDLYGFMIGREKLGQYFLTEDPSWAMDFAPKGRLLQPGELMTRKRLGKTLRTIAKQGASAFYEGPIADATIRALQLANGSMTLDDMSKYEIITRKPVSIDYRGYKIFSTGAPSSGAVALNTFKIIEGYNMSDPDNLNLNTHRLDEAIKFSYGNRNELGDPDFVEGIADFQSQMLDTANASATRNKISDDHTLDPTAYNPKRLSHPDSHGTSHVVTSDASGLSITLTTTVNLSFGSRLCVPETGIIMNNEMNDFSIPGVSNEFGFVPSPNNYIRPGKRPLSSITPVIVEQADGSLYVVTGAAGGSRIITATIQALWHVLDHGMTMPEALAQPRLDDQLLPAQVRFELGYDNATTAYMRAKGHNVTWTSELLSKTQGIRRLENGTFEAAAEPRQKNSGGYAV |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length577
- Mass (Da)62,328
- Last updated2014-11-26 v1
- Checksum48E34E2EF5274DC2
Keywords
- Technical term