A0A093W7K3 · A0A093W7K3_9PROT
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-16 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: SLS | ||||||
Binding site | 61 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 65 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 77 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 86 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 101 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 125-129 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GAGGV | ||||||
Binding site | 149-154 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: NRTKEK | ||||||
Binding site | 214 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 216 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 237 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 244 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Candidatus Pelagibacterales > Candidatus Pelagibacteraceae
Accessions
- Primary accessionA0A093W7K3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-88 | Shikimate dehydrogenase substrate binding N-terminal | ||||
Sequence: VIGNPIKHSLSPLVHNYWFEQNMIEATYEKVLVEEKGLEDVIQNIRQEKIVGANVTVPFKQKIIPLLDELSEVALKTSSVNTV | ||||||
Domain | 119-189 | Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase | ||||
Sequence: QSVLLIGAGGVSPSIVQALKNVSTNKVIIANRTKEKFEVLKNKFGPLVQQILWDDLRHKKFDVDLVVNSTS |
Sequence similarities
Belongs to the shikimate dehydrogenase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)30,959
- Last updated2014-11-26 v1
- ChecksumF15DA1A73D22EBD5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JPLS01000002 EMBL· GenBank· DDBJ | KFX72260.1 EMBL· GenBank· DDBJ | Genomic DNA |