A0A093W7K3 · A0A093W7K3_9PROT

  • Protein
    Shikimate dehydrogenase (NADP(+))
  • Gene
    aroE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site14-16shikimate (UniProtKB | ChEBI)
Binding site61shikimate (UniProtKB | ChEBI)
Active site65Proton acceptor
Binding site77NADP+ (UniProtKB | ChEBI)
Binding site86shikimate (UniProtKB | ChEBI)
Binding site101shikimate (UniProtKB | ChEBI)
Binding site125-129NADP+ (UniProtKB | ChEBI)
Binding site149-154NADP+ (UniProtKB | ChEBI)
Binding site214NADP+ (UniProtKB | ChEBI)
Binding site216shikimate (UniProtKB | ChEBI)
Binding site237NADP+ (UniProtKB | ChEBI)
Binding site244shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      FF85_00585

Organism names

  • Taxonomic identifier
  • Strain
    • Qinghai
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Candidatus Pelagibacterales > Candidatus Pelagibacteraceae

Accessions

  • Primary accession
    A0A093W7K3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-88Shikimate dehydrogenase substrate binding N-terminal
Domain119-189Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    273
  • Mass (Da)
    30,959
  • Last updated
    2014-11-26 v1
  • Checksum
    F15DA1A73D22EBD5
MKKFIVIGNPIKHSLSPLVHNYWFEQNMIEATYEKVLVEEKGLEDVIQNIRQEKIVGANVTVPFKQKIIPLLDELSEVALKTSSVNTVYKKNNKIIGDNTDVFGFQNSLAELVPNKIIQSVLLIGAGGVSPSIVQALKNVSTNKVIIANRTKEKFEVLKNKFGPLVQQILWDDLRHKKFDVDLVVNSTSLGLEKKEDLNFNFSSVNKSTVFYDVIYNPVQTSFLKQAEAQGHQVINGLKMFLYQALKAFQIWNKISPTIDKQLLQLMKKNLND

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPLS01000002
EMBL· GenBank· DDBJ
KFX72260.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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