A0A093V5I5 · A0A093V5I5_TALMA

Function

function

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular FunctionmRNA 5'-diphosphatase activity
Molecular Functionnuclease activity
Molecular Functionnucleotide binding
Molecular FunctionRNA binding
Biological ProcessNAD-cap decapping
Biological Processnuclear-transcribed mRNA catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Decapping nuclease
  • EC number

Gene names

    • ORF names
      GQ26_0510310

Organism names

  • Taxonomic identifier
  • Strain
    • PM1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces

Accessions

  • Primary accession
    A0A093V5I5

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-361RAI1-like

Sequence similarities

Belongs to the DXO/Dom3Z family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    42,376
  • Last updated
    2014-11-26 v1
  • Checksum
    C239BCC6CAD10C2F
MQQSDDLGHEIAYFSYDDEHNFRLDDSSMQYYYPPQPSQLPLDLSAGFETFEKLNDAPDEHLDALLDTIVALEQNTQKKCEADIVTWRGMMTKIVTAPFDMLNGFEMNATYFQIDCDKMEFAPDNLRSFIEENNSYKNAQKEIQKNQRMPPGMPSQDMMAYWGYKFEAVSVIPNAWGETSREKIEGRIHEVVNNKAQYCSVVRTGFGRVKLVLGGEVDAIWDSKPVRKEDPINWVELKTTAELVNDKEKLKYERKLLKFWAQSFLLGVPKIVVGFRDRDGMLLRLEELETHGLPGKVKREGRGSWDGNICINFTAAFLEWLKTVVNTEGTWRIRKREKSPVIEVFKIEESGHGDILSSNFVAWRTNQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPOX01000051
EMBL· GenBank· DDBJ
KFX41971.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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